Transcription Factor
| Accessions: | DLX3_Full (HumanTF2 1.0) |
| Names: | DLX3, DLX3_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | O60479 |
| Notes: | Ensembl ID: ENSG00000064195; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain; Clone source: Jolma et al. 2013 |
| Length: | 288 |
| Pfam Domains: | 27-106 Homeobox protein distal-less-like N terminal 130-186 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTV 60 61 NPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVR 120 121 MVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNR 180 181 RSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSAS 240 241 PSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY* |
| Interface Residues: | 28, 30, 130, 131, 132, 133, 171, 172, 174, 175, 178, 179, 182, 183, 186 |
| 3D-footprint Homologues: | 8a1c_A, 3d1n_M, 5zfz_A, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1mnm_C, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 6es3_K, 2ld5_A, 7q3o_C, 1jgg_B, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 4j19_B, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1puf_B, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A |
| Binding Motifs: | ERF_DLX3_1 avmGGAwryrgsyamTtr ERF_DLX3_2 rccGGAwrkvsyaaTta ETV2_DLX3_1 rcCGGAAryrrsskTAATtr ETV2_DLX3_2 acCGGAAryrvsvyaATtr ETV2_DLX3_2_3 rcCGGAAryrrgyaATTa ETV2_DLX3_2_3_4 TAATkrswacCGGAWryr GCM2_DLX3_1 aTrcGGGywkwyttAATtr GCM2_DLX3_2 aTrcGGGywrkdtAAttr MEIS1_DLX3 TGACAgsyTAATtr MGA_DLX3_1 AGGTGwTAATtr MGA_DLX3_2 yvATTAarGGTGtGAr TEAD4_DLX3_1 rCATwCCrhsyaATTA TEAD4_DLX3_2 rCATwCytyssTAATtr TEAD4_DLX3_2_3 rCATwCCdysstAAtkr TEAD4_DLX3_2_3_4 rCATwCCrmsyaATTA TFAP2C_DLX3_1 yssCysvrGGCaygggssTAATkr TFAP2C_DLX3_2 gsCCysrRGscaygskrTAATkr TFAP2C_DLX3_2_3 msCCybmrGsCaygcsymATTA TFAP4_DLX3_1 kCAGsTGdvggrsgyaATkr TFAP4_DLX3_2 yCAGsTGkdbgkrsgtaATtr TFAP4_DLX3_2_3 AwCAGCTGATywTAATtr TFAP4_DLX3_2_3_4 AwCAGCTGwTysssgYaatkr |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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