Transcription Factor

Accessions: P23813 (JASPAR 2024)
Names: Homeobox protein Hox-4.6, Homeobox protein Hox-5.5, Homeobox protein Hox-D11, HXD11_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 323
Pfam Domains: 13-176 Protein of unknown function (DUF3528)
252-308 Homeobox domain
Sequence:
(in bold interface residues)
1 MYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKW 60
61 PYRGGGGGGAGGGGGGGPGGGGGGSGGYAPYYAAAAAAAAAAAAAEEAAMQRDLLPPAGR 120
121 RPDVLFKAPEPVCGAPGPPHGPAAAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQP 180
181 QPAPAPPQPEGAADKGDPKPGAGGGGGSPCAKATPGPEPKGAAEGGGGEGEGPPGEAGAE 240
241 KSGGTVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQ 300
301 NRRMKEKKLNRDRLQYFTGNPLF
Interface Residues: 250, 251, 252, 253, 254, 255, 293, 294, 296, 297, 300, 301, 304, 305, 308
3D-footprint Homologues: 6fqp_B, 3a01_E, 3d1n_M, 1fjl_B, 6a8r_A, 1ig7_A, 2h1k_B, 5zfz_A, 1puf_A, 3cmy_A, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 7q3o_C, 2ld5_A, 6es3_K, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 5hod_A, 2hos_A, 6m3d_C, 1b72_A, 5jlw_D, 4xrs_G, 7psx_B, 3rkq_B, 5flv_I, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 1le8_A, 1mnm_C, 1k61_B, 6fqq_E, 4qtr_D, 1o4x_A, 1le8_B, 1du0_A
Binding Motifs: PH0076.1 ywarGTCGTAAAawyht
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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