Transcription Factor

Accessions: FOXO4_HUMAN (HOCOMOCO 10), P98177 (JASPAR 2024)
Names: Fork head domain transcription factor AFX1, Forkhead box protein O4, FOXO4_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P98177
Length: 505
Pfam Domains: 104-185 Fork head domain
Sequence:
(in bold interface residues)
1 MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHT 60
61 EGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEK 120
121 RLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWML 180
181 NPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSG 240
241 SPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTL 300
301 NEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCF 360
361 SSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLE 420
421 APGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPTEAASQDRMPQDLDLDMYMENLE 480
481 CDMDNIISDLMDEGEGLDFNFEPDP
Interface Residues: 146, 149, 151, 152, 153, 155, 156, 157, 159, 160, 169, 174, 193, 347
3D-footprint Homologues: 3l2c_A, 7vox_H, 2hdc_A, 7yzg_A, 7tdw_A, 7yz7_A, 6nce_A, 2uzk_A, 7tdx_A, 2a07_J, 7yzb_A, 3co6_C, 7vou_C, 6ako_C, 2c6y_A, 7yze_A, 7cby_C, 3g73_A, 6el8_A, 3qrf_G, 6w64_A
Binding Motifs: MA0848.1 GTAAACA
FOXO4_HUMAN.H10MO.C|M01164 TTGTTTWyk
Publications: Furuyama T., Nakazawa T., Nakano I., Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349:629-634 (2000). [Pubmed]
Related annotations: PaperBLAST

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