Transcription Factor
| Accessions: | ETV2_TF1 (HumanTF2 1.0), ETV2 (HT-SELEX2 May2017) |
| Names: | ETS translocation variant 2, ETV2, ETV2 protein, Q3KNT2_HUMAN, ENSG00000105672 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q3KNT2 |
| Notes: | Ensembl ID: ENSG00000105672; Construct type: TF1(SBP); TF family: ETS; Clone source: Jolma et al. 2013, TF family: ETS experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: ETS experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 124 |
| Pfam Domains: | 23-103 Ets-domain |
| Sequence: (in bold interface residues) | 1 EPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVA 60 61 RLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRG 120 121 AETQ |
| Interface Residues: | 75, 76, 78, 79, 80, 82, 83, 97 |
| 3D-footprint Homologues: | 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A |
| Binding Motifs: | ETV2_BHLHA15 rsCGGAAmCATATGk ETV2_CEBPD rsCGGAwrTTrCGyAAy ETV2_CLOCK rmCACGTGbcayacCGGAwry ETV2_DLX2_1 acCGGAWrTwrmbyAATTR ETV2_DLX2_2 rsMGGAAryvvsyaATTA ETV2_DLX3_1 rcCGGAAryrrsskTAATtr ETV2_DLX3_2 acCGGAAryrvsvyaATtr ETV2_DLX3_2_3 rcCGGAAryrrgyaATTa ETV2_DLX3_2_3_4 TAATkrswacCGGAWryr ETV2_DRGX_1 rsCGGAWryaATTA ETV2_DRGX_2 rcCGGAwryatTa ETV2_EOMES_1 agGYGtkamvtksmrttsrCrcMGGAwryg ETV2_EOMES_2 TcrCRCMGGAwry ETV2_EOMES_2_3 aCCGGAwryrmmwhyymACACctw ETV2_ETV7 asmGGAMGGAydTCCksb ETV2_EVX1 asCGGwAATkrymrTTwm ETV2_FIGLA_1 rsCGGAArCAGsTGgd ETV2_FIGLA_2 rvCAssTGbtrdacCGGAwgyg ETV2_FOXI1_1 sgtaaACAGGAwRyr ETV2_FOXI1_2 rCCGGAAGTmwACA ETV2_FOXI1_2_3 rcCGGAAryrtmmACAy ETV2_FOXI1_2_3_4 rcCGGATGTTkw ETV2_FOXI1_2_3_4_5 TGTtkmCGGAWGtg ETV2_FOXO6 rCCGGAWGTTkwy ETV2_GSC2_1 aCCGGAwrymmbkcmcTAATCcc ETV2_GSC2_2 aCCGGAwryrsvcvmTAATCck ETV2_GSC2_2_3 rcCGGAAryscmmcTAATcym ETV2_GSC2_2_3_4 rsCGGAwrtrsgGATTA ETV2_GSC2_2_3_4_5 rvCGGAwrtkrsggATTA ETV2_HES7_1 ggCrCGyGsckrcCGGAwry ETV2_HES7_2 rcCGGAAryrrggCrCGYGyc ETV2_HES7_2_3 rsCGGAwrygrhggCrCGyGsc ETV2_HOXA2_1 acCGGAAGTmaTta ETV2_HOXA2_2 rcCGGAwryrawrgymATTA ETV2_HOXB13_1 rvCGGAwrymrTwAam ETV2_HOXB13_2 aCCGGAwmyATwAAm ETV2_NHLH1_1 mGCAGCTGCCGGAWgyw ETV2_NHLH1_2 wcmGGAwgkramGCAGCTGCk ETV2_ONECUT2_1 rrTCrATAmCGGAAryr ETV2_ONECUT2_2 rATCrATaacCGGAAryg ETV2_ONECUT2_2_3 rcCGGAArygryATCGATy ETV2_ONECUT2_2_3_4 acCGGAWryrrrkATCGATy ETV2_ONECUT2_2_3_4_5 rcCGGAAryrrgsrATCrATr ETV2_PAX5 aCCGGAACyACGCwTsAcyg ETV2_PITX1 rsCGGAArtrrrGGmTTAg ETV2_RFX5_1 crCwTCCGsysshrGCAACss ETV2_RFX5_2 rCCGGAArymvCmTAGCAACs ETV2_RFX5_2_3 sryTTCCGGywyrGcAACgr ETV2_RFX5_2_3_4 acCGGAwrygcrcmyrGCAACg ETV2_SOX15_1 rcCGGAWgtrvgkbywTTGT ETV2_SOX15_2 rsCGGAAryrsbyyAtTGT ETV2_SOX15_2_3 rCCGGAWGyamrmACAAwrg ETV2_SOX15_2_3_4 aCCGGAWryvrwraACAAwrs ETV2_SPDEF vsMGGAmGGAwrTCCGsyt ETV2_SREBF2_1 rTCACGysACCGGAwr ETV2_SREBF2_2 vTsrSGTGACGGAAry ETV2_TBX21_1 gGTGTkAaarmkrkkTvwCRCmGGAwrk ETV2_TBX21_2 TmrCrCmGGAwry ETV2_TBX21_2_3 aCCGGAwryrmvmhyYmACACCTy ETV2_TCF3 CAssTGmacCGGAwrys ETV2_TEF_1 rCCGGAwrTTACGTAAy ETV2_TEF_2 TTACGTAAccmmgwACCGGAAry ETV2_2 raCCGGAWrtr ETV2_methyl_1 rrCAGGAArTr |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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