Transcription Factor

Accessions: T120865_1.02 (CISBP 1.02), UP00355A (UniPROBE 20160601), P22035 (JASPAR 2024)
Names: BAS1, T120865_1.02;, Myb-like DNA-binding protein BAS1, YKR099W, BAS1_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Description: Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
Notes: experiment type:PBM, family:Myb/SANT
Length: 811
Pfam Domains: 42-127 Myb-like DNA-binding domain
116-159 Myb-like DNA-binding domain
119-163 Myb-like DNA-binding domain
171-212 Myb-like DNA-binding domain
172-213 Myb-like DNA-binding domain
Sequence:
(in bold interface residues)
1 MSNISTKDIRKSKPKRGSGFDLLEVTESLGYQTHRKNGRNSWSKDDDNMLRSLVNESAKE 60
61 LGYENGLEDVKTIQQSNHLSKCIAWDVLATRFKHTVRTSKDVRKRWTGSLDPNLKKGKWT 120
121 QEEDEQLLKAYEEHGPHWLSISMDIPGRTEDQCAKRYIEVLGPGSKGRLREWTLEEDLNL 180
181 ISKVKAYGTKWRKISSEMEFRPSLTCRNRWRKIITMVVRGQASEVITKAIKENKNIDMTD 240
241 GKLRQHPIADSDIRSDSTPNKEEQLQLSQQNNPSLIKQDILNVKENESSKLPRLKDNDGP 300
301 ILNDSKPQALPPLKEISAPPPIRMTQVGQTHTSGSIRSKVSLPIEGLSQMNKQSPGGISD 360
361 SPQTSLPPAFNPASLDEHMMNSNSISDSPKHAYSTVKTREPNSSSTQWKFTLKDGQGLSI 420
421 SNGTIDSTKLVKELVDQAKKYSLKISIHQHIHNHYVTSTDHPVSSNTGLSNIGNINGNPL 480
481 LMDSFPHMGRQLGNGLPGLNSNSDTFNPEYRTSLDNMDSDFLSRTPNYNAFSLEATSHNP 540
541 ADNANELGSQSNRETNSPSVFYPQANTLIPTNSTATNNEIIQGNVSANSMSPNFNGTNGK 600
601 APSSTASYTTSGSEMPPDVGPNRIAHFNYLPPTIRPHLGSSDATRGADLNKLLNPSPNSV 660
661 RSNGSKTKKKEKRKSESSQHHSSSSVTTNKFNHIDQSEISRTTSRSDTPLRDEDGLDFWE 720
721 TLRSLATTNPNPPVEKSAENDGAKPQVVHQGIGSHTEDSSLGSHSGGYDFFNELLDKKAD 780
781 TLHNEAKKTSEHDMTSGGSTDNGSVLPLNPS
Interface Residues: 100, 103, 104, 108, 116, 149, 150, 151, 152, 154, 155, 158, 159, 160, 203, 204, 207, 208, 211, 522, 553, 555, 558, 559, 560, 561, 562
3D-footprint Homologues: 3zqc_A, 6kks_A, 7xur_A, 3osg_A, 2kdz_A, 1mse_C, 5eyb_B, 1w0t_A, 8fcj_E
Binding Motifs: MA0278.1 kcwyrgCCvGAGTCArdwyra
UP00355A_1 kcwyrrCCvGAGTCArdwyra
M1375_1.02 MmGAGTCA
MA0278.2 rgCCvGAGTCAr
Binding Sites: ACGAGTCA
AGAGTCAA
AGAGTCAC
AGGAGTCA
CAGAGTCA
CCAGAGTC
CCCGAGTC
CCGAGTCA
CGAGTCAA
CGAGTCAG
CGGAGTCA
CTGACTCC
GACTCCTC
GAGTCAAA
GGAGTCAC
ACAGAGTC
ACTGACTC
AGACTCTG
CGAGTCAC
GACTCTGC
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]

Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.