Transcription Factor

Accessions: Q96BA8 (JASPAR 2024)
Names: cAMP-responsive element-binding protein 3-like protein 1, CR3L1_HUMAN, Cyclic AMP-responsive element-binding protein 3-like protein 1, OASIS, Old astrocyte specifically-induced substance
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q96BA8
Length: 519
Pfam Domains: 288-350 bZIP transcription factor
291-341 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFD 60
61 DPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQDAEHGAWALG 120
121 HKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQL 180
181 PVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTA 240
241 ISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKN 300
301 KISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLVTNK 360
361 ISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTASQM 420
421 PSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTK 480
481 YLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS
Interface Residues: 208, 210, 296, 297, 300, 301, 303, 304, 306, 307, 308, 310, 311
3D-footprint Homologues: 2nra_C, 7x5e_E, 1nwq_C, 7x5e_F, 1skn_P, 6mg1_B, 5t01_B, 5vpe_D, 7z5k_B, 2dgc_A, 1dh3_C
Binding Motifs: MA0839.1 rTGCCACGTCAyCa
MA0839.2 TGCCACGTCAyCa
Publications: Fox RM, Hanlon CD, Andrew DJ. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. J Cell Biol 191:479-92 (2010). [Pubmed]
Related annotations: PaperBLAST

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