Transcription Factor
| Accessions: | T153746_1.02 (CISBP 1.02), UP00275A (UniPROBE 20160601), Q12427 (JASPAR 2024) |
| Names: | STB3, T153746_1.02;, "Protein STB3, SIN3-binding protein 3, YD9489.04c, YDR169C", Protein STB3, STB3_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Protein that binds Sin3p in a two-hybrid assay |
| Notes: | experiment type:PBM |
| Length: | 513 |
| Pfam Domains: | 44-128 Putative Sin3 binding protein |
| Sequence: (in bold interface residues) | 1 MSENQKEVSPPQAISVKSEASSSIFSKPISTSSPAGLAAAQRVTPGKLSTLLLEMGPLAI 60 61 RHITQTLCLDIPCFKDLSSSKQRRLIMSAMESGDKEKSVVFEKIGWGQWSAKRVDPANFD 120 121 KELEATNFANAKVKDLISQESQRRKSNNSNSNSGGKVEMPMKVEHNITNIDGATTPPTAV 180 181 ASTTIPVNIKRSKSPLAAANVVYIDENALASEDEDEEFDEDDHHLHYQNKSRNSSNNFGK 240 241 SSNGDPYSFGRRRSQVVFADSTPENIEHEIIAQKIRPLLRNRRRSSIKPHTPFISKLNTH 300 301 QDSSYLSPNTTSTTTPSNNNSNSNQAKIDLEKLTATSEPTSRRASRLSVSKESSIRSTLF 360 361 PNKNYLIVTTNPNSKATSVSTSPKLEEQMNVSSNPIVLSDKEKHRVASQHLNGESSPQLV 420 421 PHSHHQPHSDTDEEDWESIGAASLRNNSLAPNIDSVASSTNGVVSPKPTNPSFTNSQNGD 480 481 IEPPLQHDQQKHEQQPRNGEDNSAAFLLMSLKS |
| Interface Residues: | 369, 370, 396, 478, 480, 482 |
| 3D-footprint Homologues: | 1h6f_B, 8hnv_A |
| Binding Motifs: | MA0390.1 gtyyaaAwTTTTTCActyhkk UP00275A_1 gtyyaaAwTTTTTCActyhkk M1674_1.02 awwTTTTCAm MA0390.2 AwTTTTTCAct |
| Binding Sites: | AAAATTTC AAATTTCA AATTTCAC AATTTCAT AATTTTCA AATTTTTC ATATTTCA ATGAAAAA ATTTTCAA ATTTTTCA CTGAAAAA CTTTTTCA GTGAAAAA GTTTTTCA TGAAAAAA TGGAAAAA TTGAAAAA ATTTTTCG GAAATTTC GAATTTCA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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