Transcription Factor
| Accessions: | grh (DrosophilaTF 1.1), P13002 (JASPAR 2024) |
| Names: | DNA-binding protein ELF-1, Element I-binding activity, ELF1_DROME, Protein grainy-head, Protein grainyhead, Transcription factor NTF-1 |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P13002 |
| Length: | 1334 |
| Pfam Domains: | 888-1091 CP2 transcription factor |
| Sequence: (in bold interface residues) | 1 MSTSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGS 60 61 GGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAV 120 121 FIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDE 180 181 NQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAM 240 241 YNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAA 300 301 GGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKS 360 361 LEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQSGKLNG 420 421 QTTPIDVSGLSQNEIQGFLLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQ 480 481 QHQQQQQHPGDIVSAAGVGSTGSIVSSAAQQQQQQQLISIKREPEDLRKDPKNGNIAGAA 540 541 TANGPGSVITQKILHVDAPTASEADRPSTPSSSINSTENTESDSQSVSGSESGSPGARTT 600 601 ATLEMYATTGGTQIYLQTSHPSTASGAGGGAGPAGAAGGGGVSMQAQSPSPGPYITANDY 660 661 GMYTASRLPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTRSLYGDVDVSVSQPGG 720 721 VVTYEGRFAGSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSN 780 781 GGATPLYAKAITAAGLTVDLPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANG 840 841 SIPVSVNSIQQRTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDADKIQIPKIFTN 900 901 VGFRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKNTTVKSVIMLMFRE 960 961 EKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSHNAIAVYWNPLE SSA 1020 1021 KINIAVQCLSTDFSSQKGVKGLPLHVQIDTFEDPRDTAVFHRGYCQIKVFCDKGAERKTR 1080 1081 DEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIG 1140 1141 AATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHF 1200 1201 PPDMQTDKKDHILDQNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHV 1260 1261 VPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIE 1320 1321 DDLYDVTLTELPNQ |
| Interface Residues: | 195, 196, 199, 200, 202, 203, 217, 848, 1071, 1076, 1079 |
| 3D-footprint Homologues: | 4mhg_A, 1bf5_A, 5mpf_B |
| Binding Motifs: | grh ynAACyGGTyyTGCGG MA1457.1 raAACCrGTTtty MA1457.2 aAACCrGTTt |
| Binding Sites: | MA1457.1.1 / MA1457.1.3 MA1457.1.10 MA1457.1.11 MA1457.1.12 MA1457.1.13 MA1457.1.14 MA1457.1.15 MA1457.1.16 MA1457.1.17 MA1457.1.18 MA1457.1.19 MA1457.1.2 / MA1457.1.4 MA1457.1.20 MA1457.1.5 MA1457.1.6 MA1457.1.7 MA1457.1.8 MA1457.1.9 MA1457.2.1 / MA1457.2.2 / MA1457.2.3 / MA1457.2.4 MA1457.2.10 / MA1457.2.15 / MA1457.2.16 MA1457.2.11 / MA1457.2.14 / MA1457.2.17 MA1457.2.12 MA1457.2.13 MA1457.2.18 MA1457.2.19 MA1457.2.20 MA1457.2.5 MA1457.2.6 MA1457.2.7 MA1457.2.8 MA1457.2.9 |
| Publications: | Dynlacht B. D., Attardi L. D., Admon A., Freeman M., Tjian R. Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. Genes Dev. 3:1677-1688 (1989). [Pubmed] Yao L, Wang S, Westholm JO, Dai Q, Matsuda R, Hosono C, Bray S, Lai EC, Samakovlis C. Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl. Development 144:3145-3155 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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