Transcription Factor
| Accessions: | TF7L2_HUMAN (HOCOMOCO 10), Q9NQB0 (JASPAR 2024) |
| Names: | HMG box transcription factor 4, hTCF-4, T-cell factor 4, T-cell-specific transcription factor 4, TCF-4, TF7L2_HUMAN, Transcription factor 7-like 2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 619 |
| Pfam Domains: | 1-259 N-terminal CTNNB1 binding 350-417 HMG (high mobility group) box 351-408 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 60 61 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 120 121 LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP 180 181 AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS 240 241 PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP 300 301 HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY 360 361 MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR 420 421 DNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPC 480 481 RRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKP 540 541 DPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSH 600 601 SSLAGTQPQPLSLVTKSLE |
| Interface Residues: | 352, 355, 357, 358, 361, 365, 376, 377, 378, 381, 419, 421, 423, 426, 428, 429, 430, 433, 465, 482, 483, 484 |
| 3D-footprint Homologues: | 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 2gzk_A, 4s2q_D, 7m5w_A, 2lef_A, 4y60_C, 1hry_A, 7dta_A |
| Binding Motifs: | MA0523.1 rrAswTCAAAGgva TF7L2_HUMAN.H10MO.A|M01568 tbyCTTTGAwsTy MA0523.2 AswTCAAAG |
| Binding Sites: | MA0523.1.1 MA0523.1.10 MA0523.1.11 MA0523.1.12 MA0523.1.13 MA0523.1.14 MA0523.1.15 MA0523.1.16 MA0523.1.17 MA0523.1.18 MA0523.1.19 MA0523.1.2 MA0523.1.20 MA0523.1.3 MA0523.1.4 MA0523.1.5 MA0523.1.6 MA0523.1.7 MA0523.1.8 MA0523.1.9 MA0523.2.1 MA0523.2.10 MA0523.2.11 MA0523.2.12 MA0523.2.13 MA0523.2.14 MA0523.2.15 MA0523.2.16 MA0523.2.17 MA0523.2.18 MA0523.2.19 MA0523.2.2 MA0523.2.20 MA0523.2.3 MA0523.2.4 MA0523.2.5 MA0523.2.6 MA0523.2.7 MA0523.2.8 MA0523.2.9 |
| Publications: | Hatzis P, van der Flier L.G, van Driel M.A, Guryev V, Nielsen F, Denissov S, Nijman I.J, Koster J, Santo E.E, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, Stunnenberg H.G. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Molecular and cellular biology 28:2732-44 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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