Transcription Factor

Accessions: ERG_DBD (HumanTF 1.0), ERG_TF1 (HumanTF2 1.0), ERG_TF2 (HumanTF2 1.0)
Names: ERG, ERG_HUMAN, Transcriptional regulator ERG, Transforming protein ERG, Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, KCNH2_HUMAN, Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P11308
Notes: Ensembl ID: ENSG00000157554; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000157554; Construct type: TF1(SBP); TF family: ETS; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000157554; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013
Length: 302
Pfam Domains: 22-104 Sterile alpha motif (SAM)/Pointed domain
193-275 Ets-domain
Sequence:
(in bold interface residues)
1 MASPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP 60
61 DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQ 120
121 NSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILG 180
181 PTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK 240
241 PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPY 300
301 MG
Interface Residues: 191, 246, 247, 249, 250, 251, 253, 254, 268
3D-footprint Homologues: 3zp5_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 8ee9_F, 4mhg_A, 2stt_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C
Binding Motifs: ERG_DBD_1 ACCGGAArTg
ERG_DBD_2 aCCGGAwATCCGgt
GCM1_ERG rTGCGGGCGGaarkg
TEAD4_ERG_1 ACCGGAAATrCc
TEAD4_ERG_2 aCCGGAArTrvawgrcATwCC
TEAD4_ERG_2_3 rCCGGAAATrCC
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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