Transcription Factor
| Accessions: | POU5F1 (HT-SELEX2 May2017), PO5F1_HUMAN (HOCOMOCO 10), Q01860 (JASPAR 2024) |
| Names: | ENSG00000204531, POU5F1, Oct-3, Oct-4, Octamer-binding protein 3, Octamer-binding protein 4, Octamer-binding transcription factor 3, OTF-3, PO5F1_HUMAN, POU domain, class 5, transcription factor 1 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: POU experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: POU experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 360 |
| Pfam Domains: | 141-212 Pou domain - N-terminal to homeobox domain 231-287 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGI 60 61 PPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG 120 121 AVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS 180 181 QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENR 240 241 VRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEA 300 301 AGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN 360 |
| Interface Residues: | 164, 180, 181, 182, 183, 185, 186, 192, 196, 230, 231, 232, 233, 234, 235, 272, 275, 276, 279, 280, 282, 283, 284, 287 |
| 3D-footprint Homologues: | 3d1n_M, 7u0g_M, 3l1p_A, 2xsd_C, 1o4x_A, 7xrc_C, 8g87_X, 1e3o_C, 1au7_A, 3a01_E, 1ig7_A, 5zfz_A, 1puf_A, 3cmy_A, 2h1k_B, 1fjl_B, 6a8r_A, 1zq3_P, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 6es3_K, 7q3o_C, 2hdd_A, 1b72_A, 4xrs_G, 2hos_A, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 5jlw_D, 1le8_A, 4xrm_B, 1du0_A, 4cyc_A, 2d5v_B, 5flv_I, 5zjt_E, 4qtr_D, 3vw3_H |
| Binding Motifs: | POU5F1_4 rawTATGywAATkarg POU5F1_methyl_1 rawTATGywAATkArg POU5F1_methyl_2 rTTAATTATGCGyrw POU5F1_methyl_3 wTATGCGCATAw PO5F1_HUMAN.H10MO.A|M01453 cywTTswtATGCAaAt MA1115.1 wwATGCAAAtd MA1115.2 ATGCAAA |
| Binding Sites: | MA1115.1.1 MA1115.1.10 MA1115.1.11 MA1115.1.12 MA1115.1.13 MA1115.1.14 MA1115.1.15 MA1115.1.16 MA1115.1.17 MA1115.1.18 MA1115.1.19 MA1115.1.2 MA1115.1.20 MA1115.1.3 MA1115.1.4 MA1115.1.5 MA1115.1.6 MA1115.1.7 MA1115.1.8 MA1115.1.9 MA1115.2.1 MA1115.2.10 MA1115.2.11 / MA1115.2.9 MA1115.2.12 / MA1115.2.17 / MA1115.2.5 / MA1115.2.7 MA1115.2.13 / MA1115.2.14 / MA1115.2.15 / MA1115.2.19 / MA1115.2.3 / MA1115.2.4 / MA1115.2.6 / MA1115.2.8 MA1115.2.16 MA1115.2.18 MA1115.2.2 MA1115.2.20 |
| Publications: | Zhao FQ. Octamer-binding transcription factors: genomics and functions. Front Biosci (Landmark Ed) : (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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