Transcription Factor

Accessions: T049021_1.02 (CISBP 1.02), O88282 (JASPAR 2024)
Names: Bcl6b, T049021_1.02;, B-cell CLL/lymphoma 6 member B protein, Bcl6-associated zinc finger protein, BCL6B_MOUSE
Organisms: Mus musculus
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:C2H2 ZF
Length: 474
Pfam Domains: 28-134 BTB/POZ domain
323-345 Zinc finger, C2H2 type
323-345 C2H2-type zinc finger
337-361 Zinc-finger double domain
351-369 Zinc-finger of C2H2 type
351-373 Zinc finger, C2H2 type
351-371 C2H2-type zinc finger
365-389 Zinc-finger double domain
379-401 Zinc finger, C2H2 type
379-401 C2H2-type zinc finger
393-418 Zinc-finger double domain
407-429 C2H2-type zinc finger
407-429 Zinc finger, C2H2 type
422-445 Zinc-finger double domain
Sequence:
(in bold interface residues)
1 MGSTAAPEGALGYVREFTRHSSDVLSNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACS 60
61 GFFYSIFRGRAGLGVDVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQM 120
121 EHVVQACHRFIQASYEPLGISLRPVEVEPPRPPTVAPPGSPRRSEGHPDPPTESRSCSQG 180
181 SPSPASPDPKACNWKKYKFIVLNSQTSQAGSLVGESSGQPCPQARLPSGDEACSSSSSSE 240
241 EGTTPGLQSRLSLATTTARFKCGALANNSYLFTPRAQETSLPASKQANPPPGSEFFSCQN 300
301 CEAVAGCSSGLELLAPGDEDKPYKCQLCRSAFRYKGNLASHRTVHTGEKPYRCSICGARF 360
361 NRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQ 420
421 TLKSHVRIHTGEKPYHCDPCGLHFRHKSQLRLHLRQKHGAATNTKVRYHILGGP
Interface Residues: 307, 309, 310, 313, 333, 334, 335, 336, 337, 339, 340, 342, 343, 344, 346, 351, 361, 362, 363, 364, 365, 367, 368, 372, 389, 390, 391, 392, 393, 395, 396, 397, 417, 418, 419, 420, 421, 422, 423, 424, 425, 427, 446, 447, 448, 449, 450, 451, 452
3D-footprint Homologues: 7w1m_H, 5v3j_F, 7y3l_A, 7n5w_A, 5kkq_D, 6wmi_A, 8ssq_A, 5und_A, 2gli_A, 8ssu_A, 6ml4_A, 8gn3_A, 8h9h_G, 7eyi_G, 7y3m_I, 7ysf_A, 2i13_A, 5yel_A, 2jpa_A, 1ubd_C, 2kmk_A, 1tf3_A, 6jnm_A, 8cuc_F, 6blw_A, 6u9q_A, 5ei9_F, 1mey_C, 5kl3_A, 1f2i_J, 5k5i_A, 1g2f_F, 1tf6_A, 4x9j_A, 1llm_D, 6e94_A, 2lt7_A, 7txc_E, 2drp_D, 5yj3_D, 4m9v_C, 6a57_A, 3uk3_C, 2wbs_A, 5k5l_F
Binding Motifs: PB0006.1 wcTTTCkAGGAAttys
PB0110.1 hbscCCgCCCCwhmwm
M0391_1.02 tyctrGRAarrm
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.