Transcription Factor
| Accessions: | T014178_1.02 (CISBP 1.02), AHR_HUMAN (HOCOMOCO 10) |
| Names: | AHR, T014178_1.02;, Ah receptor, AHR_HUMAN, Aryl hydrocarbon receptor, bHLHe76, Class E basic helix-loop-helix protein 76 |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] |
| Notes: | family:bHLH |
| Length: | 848 |
| Pfam Domains: | 37-78 Helix-loop-helix DNA-binding domain 114-226 PAS fold 300-382 PAS fold |
| Sequence: (in bold interface residues) | 1 MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDV 60 61 INKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQ 120 121 ALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP 180 181 SQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQ 240 241 GKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGC 300 301 DAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRW 360 361 TWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF 420 421 PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAP 480 481 FENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLY 540 541 SIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQ 600 601 QQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFV 660 661 PFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYP 720 721 MGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQH 780 781 THVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP 840 841 DLTSSGFL |
| Interface Residues: | 32, 33, 34, 35, 36, 37, 39, 40, 41 |
| 3D-footprint Homologues: | 8osl_O, 4h10_B, 7xi3_A, 4zpk_B, 4h10_A, 4zpr_B, 8osl_P, 5nj8_D, 7xi3_B, 5sy7_B, 5v0l_A, 7xhv_B, 5nj8_C, 4zpk_A, 7d8t_A, 6g1l_A, 5v0l_B |
| Binding Motifs: | M2917_1.02 wstCACGCwAsyysGrrg AHR_HUMAN.H10MO.B|M01001 dtyGCGTGm |
| Related annotations: | PaperBLAST |
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