Transcription Factor
| Accessions: | O95948 (JASPAR 2024) |
| Names: | Hepatocyte nuclear factor 6-beta, HNF-6-beta, OC-2, One cut domain family member 2, One cut homeobox 2, ONEC2_HUMAN, Transcription factor ONECUT-2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O95948 |
| Length: | 504 |
| Pfam Domains: | 328-406 CUT domain 427-480 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE 60 61 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYR 120 121 PELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHH 180 181 HHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLH 240 241 NAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGH 300 301 TQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRV 360 361 LCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNK 420 421 DRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRR 480 481 SLEKWQDDLSTGGSSSTSSTCTKA |
| Interface Residues: | 357, 358, 359, 362, 363, 364, 365, 367, 369, 370, 373, 377, 402, 403, 408, 412, 428, 429, 430, 471, 472, 475, 476, 479, 480, 484 |
| 3D-footprint Homologues: | 1au7_A, 2d5v_B, 2o4a_A, 1e3o_C, 3l1p_A, 2lkx_A, 7q3o_C, 6es3_K, 2hdd_A, 5hod_A, 2hos_A, 3rkq_B, 8g87_X, 4qtr_D, 6fqp_B, 4xrm_B, 6fqq_E, 1o4x_A, 1puf_B |
| Binding Motifs: | MA0756.1 aaaAAATCrATAww UN0492.1 wdsGCGCsmwTATyGAyy UN0493.1 wdsGCGCshwwTATCGAyy MA0756.2 cGATCrATA MA0756.3 GATCrATA UN0492.2 GCGCsmwTATyGAy UN0493.2 GCGCshwwTATCGAy |
| Publications: | Samadani U., Costa R. H. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:6273-6284 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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