Transcription Factor

						

			
Accessions: BHLHE40 (HT-SELEX2 May2017)

			
Names: BHLHE40, ENSG00000134107
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2
Length: 115
Pfam Domains:     28-78 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 PAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG   60
  61 HLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCS
Interface Residues: 27, 28, 29, 31, 32, 35, 36, 62
3D-footprint Homologues: 1an4_A, 6g1l_A, 4zpk_A, 7ssa_L, 5nj8_D, 7d8t_A, 5v0l_A, 4h10_A, 7f2f_B, 5eyo_A, 1a0a_B, 7xi3_A, 7rcu_E, 1am9_A, 8osl_P, 8osl_O, 7xhv_B, 4h10_B, 4zpr_B, 5nj8_C, 7xi3_B, 5v0l_B
Binding Motifs: BHLHE40_2 gTCACGTGAc
BHLHE40_methyl_1 gTCACGTGAc
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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