Transcription Factor
| Accessions: | P70314 (JASPAR 2024) |
| Names: | Hindlimb-expressed homeobox protein backfoot, Homeobox protein P-OTX, Homeobox protein PITX1, Paired-like homeodomain transcription factor 1, Pituitary homeobox 1, Pituitary OTX-related factor, PITX1_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P70314 |
| Length: | 315 |
| Pfam Domains: | 91-147 Homeobox domain 276-295 OAR domain |
| Sequence: (in bold interface residues) | 1 MDAFKGGMSLERLPEGLRPPPPPPHDMGPSFHLARAADPREPLENSASESSDADLPDKER 60 61 GGEAKGPEDGGAGSAGCGGGAEDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMR 120 121 EEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAAGY 180 181 SYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPN 240 241 SGLNNINNLTGSSLNSAMSPGACPYGTPASPYSVYRDTCNSSLASLRLKSKQHSSFGYGG 300 301 LQGPASGLNACQYNS |
| Interface Residues: | 89, 90, 91, 92, 93, 94, 96, 132, 133, 135, 136, 139, 140, 143, 144, 147, 148 |
| 3D-footprint Homologues: | 1qum_A, 4j19_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 2h1k_B, 3d1n_M, 1fjl_B, 5zfz_A, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 6m3d_C, 1b72_A, 5flv_I, 3l1p_A, 2hos_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 1mnm_C, 5jlw_D, 3rkq_B, 1puf_B, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 1k61_B, 1le8_A, 1e3o_C, 1au7_A, 1o4x_A, 1le8_B, 1du0_A, 4qtr_D, 8g87_X |
| Binding Motifs: | MA0682.1 yTAATCCc PH0137.1 tkrrrGGGATTAAmaah |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Lamonerie T., Tremblay J. J., Lanctot C., Therrien M., Gauthier Y., Drouin J. Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev. 10:1284-1295 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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