Transcription Factor
| Accessions: | HOXA13_DBD (HumanTF 1.0), HOXA13_TF2 (HumanTF2 1.0), HXA13_HUMAN (HOCOMOCO 10), P31271 (JASPAR 2024) |
| Names: | Homeobox protein Hox-1J, Homeobox protein Hox-A13, HOXA13, HXA13_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HOCOMOCO 10 3, JASPAR 2024 4 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 4 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P31271 |
| Notes: | Ensembl ID: ENSG00000106031; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000106031; Construct type: TF2(3xFLAG); TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013 |
| Length: | 388 |
| Pfam Domains: | 79-133 Hox protein A13 N terminal 124-224 Hox protein A13 N terminal 323-379 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPH 60 61 PAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAA 120 121 AAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYP 180 181 CARMGPHPNAIKSCAQPASAAAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPY 240 241 HHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPH 300 301 LWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTN 360 361 LSERQVTIWFQNRRVKEKKVINKLKTTS |
| Interface Residues: | 323, 324, 325, 326, 364, 365, 367, 368, 371, 372, 375, 376, 379 |
| 3D-footprint Homologues: | 2h1k_B, 5zfz_A, 1puf_A, 1ig7_A, 3cmy_A, 6a8r_A, 1fjl_B, 2lkx_A, 6m3d_C, 2p0j_A, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 7q3o_C, 2ld5_A, 6es3_K, 1b72_A, 3rkq_B, 5flv_I, 3a01_E, 2hdd_A, 5zjt_E, 4cyc_A, 1puf_B, 5hod_A, 2hos_A, 2r5y_A, 7psx_B, 5jlw_D, 4xrs_G, 1le8_A, 7xrc_C, 6ryd_F, 1e3o_C, 1au7_A, 2xsd_C, 1mnm_C, 1du0_A, 4qtr_D, 1k61_B, 1o4x_A |
| Binding Motifs: | HOXA13_DBD_1 cCmATAAAam HOXA13_DBD_2 sCTCGTAAAam MA0650.1 cyaATAAAam CUX1_HOXA13_1 ATCGATyAysycrTmAA CUX1_HOXA13_2 cyCrTAAAwATyGATc ETV5_HOXA13 rmcGGAwGYcgTaaa GCM1_HOXA13 rTGcGGGTmaTaAa GCM2_HOXA13 / UN0553.1 ATRCGGGTaATAAAa HOXA13_MEIS1 dmyrTAAAaCTGTC MEIS1_HOXA13 symrTaAaacTGTCA MEIS2_HOXA13 CTCGTAAAmCTGTCA MYBL1_HOXA13 CTCRTAAAwwakkrmCGTTr TEAD4_HOXA13_1 CTcGTAAATwCcr TEAD4_HOXA13_2 GGwATGCycrTWAA TEAD4_HOXA13_2_3 rCATwCCrcrmmmscymrTAAA TEAD4_HOXA13_2_3_4 rCATwCcdmrswaTTTAyrag MA0650.2 vCCMATAAAAc HXA13_HUMAN.H10MO.C|M01236 grTwTTATtGg UN0553.2 ATRCGGGTaATAAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] Knosp W. M., Saneyoshi C., Shou S., Bachinger H. P., Stadler H. S. Elucidation, quantitative refinement, and in vivo utilization of the HOXA13 DNA binding site.. J. Biol. Chem. 282:6843-6853 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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