Transcription Factor

Accessions: HLF (HT-SELEX2 May2017), HLF_HUMAN (HOCOMOCO 10), Q16534 (JASPAR 2024)
Names: ENSG00000108924, HLF, HLF_HUMAN
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 295
Pfam Domains: 224-277 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP 60
61 QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA 120
121 PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA 180
181 DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAK 240
241 RSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
Interface Residues: 231, 232, 235, 236, 238, 239, 242, 243
3D-footprint Homologues: 2wt7_A, 6mg1_B, 1nwq_C
Binding Motifs: MA0043.2 yrTTAYrTAAym
HLF_2 cgTTRYGYAAyr
HLF_methyl_1 cgTTryGyAAyg
HLF_HUMAN.H10MO.C|M01213 grTTryGTAAyms
MA0043.1 krTTACryAAth
MA0043.3 wdrTTATGYAAymw
MA0043.4 TTATGYAAy
Binding Sites: MA0043.1.1
MA0043.1.10
MA0043.1.11
MA0043.1.12
MA0043.1.13
MA0043.1.14
MA0043.1.15
MA0043.1.16
MA0043.1.17
MA0043.1.18
MA0043.1.2
MA0043.1.3
MA0043.1.4
MA0043.1.5
MA0043.1.6
MA0043.1.7
MA0043.1.8
MA0043.1.9
MA0043.3.1
MA0043.3.10 / MA0043.3.7
MA0043.3.11 / MA0043.3.8
MA0043.3.12 / MA0043.3.9
MA0043.3.10 / MA0043.3.13
MA0043.3.11 / MA0043.3.14
MA0043.3.15
MA0043.3.16
MA0043.3.17
MA0043.3.12 / MA0043.3.18
MA0043.3.19
MA0043.3.1 / MA0043.3.2
MA0043.3.20
MA0043.3.2 / MA0043.3.3
MA0043.3.4
MA0043.3.4 / MA0043.3.5
MA0043.3.5 / MA0043.3.6
MA0043.3.7
MA0043.3.8
MA0043.3.6 / MA0043.3.9
MA0043.3.13
MA0043.3.14
MA0043.3.15
MA0043.3.16
MA0043.3.17
MA0043.3.18
MA0043.3.19
MA0043.3.20
MA0043.3.3
MA0043.4.14
MA0043.4.15 / MA0043.4.20 / MA0043.4.5
MA0043.4.18 / MA0043.4.7 / MA0043.4.8
MA0043.4.6
MA0043.4.10 / MA0043.4.16 / MA0043.4.19
MA0043.4.1 / MA0043.4.2
MA0043.4.11 / MA0043.4.12 / MA0043.4.13 / MA0043.4.4
MA0043.4.17
MA0043.4.3
MA0043.4.9
Publications: Hunger S. P., Brown R., Cleary M. L. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol. Cell. Biol. 14:5986-5996 (1994). [Pubmed]
Related annotations: PaperBLAST

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