Transcription Factor

Accessions: T144625_1.02 (CISBP 1.02), Q04889 (JASPAR 2024), Q7M6Y2 (JASPAR 2024)
Names: Sox11, T144625_1.02;, SOX11_MOUSE
Organisms: Mus musculus
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Sox
Length: 395
Pfam Domains: 49-117 HMG (high mobility group) box
50-106 Domain of unknown function (DUF1898)
Sequence:
(in bold interface residues)
1 MVQQAESSEAESNLPRDALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWS 60
61 KIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRP 120
121 RKKPKTDPAAKPSAGQSPDKSAAGAKAAKGPGKKCAKLKAPAGKAGAGKAAQPGDCAAGK 180
181 AAKCVFLDDDDEDDDEDDELQLRPKPDADDDDDEPAHSHLLPPPTQQQPPQLLRRYSVAK 240
241 VPASPTLSSAAESPEGASLYDEVRAGGRLYYSFKNITKQQPPPAPPALSPASSRCVSTSS 300
301 SSGSSSGSGAEDADDLMFDLSLNFSQGAHSACEQPLGAGAAGNLSLSLVDKDLDSFSEGS 360
361 LGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY
Interface Residues: 51, 54, 56, 57, 60, 64, 75, 76, 77, 80, 118, 120, 122, 123
3D-footprint Homologues: 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 1hry_A, 3tq6_B
Binding Motifs: PB0061.1 wkwarAACAAWGraywa
PB0165.1 arAATTGTywkrrw
MA0869.1 AACAATTkCAGTGTT
M1601_1.02 wTTGTyyty
MA0869.2 rrGAACAAAGrv
MA0869.3 GAACAAAG
Binding Sites: MA0869.3.15 / MA0869.3.4
MA0869.3.1 / MA0869.3.17
MA0869.2.1 / MA0869.2.2
MA0869.2.10 / MA0869.2.17
MA0869.2.11 / MA0869.2.18
MA0869.2.12
MA0869.2.13 / MA0869.2.19
MA0869.2.14 / MA0869.2.20
MA0869.2.15
MA0869.2.16
MA0869.2.17
MA0869.2.18
MA0869.2.19
MA0869.2.2 / MA0869.2.3
MA0869.2.20
MA0869.2.3 / MA0869.2.4
MA0869.2.4 / MA0869.2.5
MA0869.2.5 / MA0869.2.8
MA0869.2.10 / MA0869.2.6
MA0869.2.12 / MA0869.2.7
MA0869.2.14 / MA0869.2.8
MA0869.2.15 / MA0869.2.9
MA0869.2.1
MA0869.2.11
MA0869.2.13
MA0869.2.16
MA0869.2.6
MA0869.2.7
MA0869.2.9
MA0869.3.10 / MA0869.3.11
MA0869.3.12
MA0869.3.13 / MA0869.3.16
MA0869.3.14 / MA0869.3.8
MA0869.3.18
MA0869.3.19 / MA0869.3.3
MA0869.3.2 / MA0869.3.6
MA0869.3.20 / MA0869.3.7
MA0869.3.5
MA0869.3.9
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

Harley VR, Clarkson MJ, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev 24:466-87 (2003). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.