Transcription Factor
| Accessions: | FLI1_HUMAN (HOCOMOCO 10), Q01543 (JASPAR 2024) |
| Names: | FLI1_HUMAN, Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 452 |
| Pfam Domains: | 114-197 Sterile alpha motif (SAM)/Pointed domain 280-362 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQ 60 61 PVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTN 120 121 ERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATT 180 181 LYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNK 240 241 SPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCI 300 301 TWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF 360 361 DFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAAS 420 421 QYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY |
| Interface Residues: | 278, 333, 334, 336, 337, 338, 340, 341, 355 |
| 3D-footprint Homologues: | 3zp5_A, 7jsa_J, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | MA0475.2 ACCGGAArTg MA0475.1 rCMGGAAGygr UN0526.1 rvCGGAwrTTGCGCAAy UN0527.1 rmmGGAwATTGCGcAAy MA1949.1 aCCGGAwGyAATTAt UN0532.1 accGGAAaCACGTGg FLI1_HUMAN.H10MO.A|M01137 rCmGGAAGyggsg MA0475.3 ACCGGAArT MA1949.2 aCCGGAwGyAATTA UN0527.2 mGGAwATTGCGcAAy UN0532.2 ccGGAAaCACGTG |
| Binding Sites: | MA0475.1.1 MA0475.1.10 MA0475.1.11 MA0475.1.12 MA0475.1.13 MA0475.1.14 MA0475.1.15 MA0475.1.16 MA0475.1.17 MA0475.1.18 MA0475.1.19 MA0475.1.2 MA0475.1.20 MA0475.1.3 MA0475.1.4 MA0475.1.5 MA0475.1.6 MA0475.1.7 MA0475.1.8 MA0475.1.9 |
| Publications: | Mao X, Miesfeldt S, Yang H, Leiden J.M, Thompson C.B. The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. The Journal of biological chemistry 269:18216-22 (1994). [Pubmed] Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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