Transcription Factor
| Accessions: | P81066 (JASPAR 2024) |
| Names: | Homeodomain protein IRXA2, Iroquois homeobox protein 2, Iroquois-class homeobox protein Irx6, Iroquois-class homeodomain protein IRX-2, IRX2_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 474 |
| Pfam Domains: | 119-175 Homeobox domain 133-172 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT 60 61 GFGSPLQYSADAAAAAAAGFPSYVGSPYDTHTTGMTGAISYHPYGSAAYPYQLNDPAYRK 120 121 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 180 181 WAPRNKSEDEDEDEGDASRSKEESSDKAQDGTETSAEDEGISLHVDSLTDHSCSAESDGE 240 241 KLPCRAGDALCESGSECKDKFEDLEDEEDEEDECERDLAPPKPVTSSPLTGVEAPLLSPA 300 301 PEAAPRGGSGGKTPLGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAA 360 361 AAPASTGAPPGGSPYSASPLLGRHLYYTSPFYGNYTNYGNLNAALQGQGLLRYNTAASSP 420 421 GETLHAMPKAASDTGKAGSHSLESHYRPPGGGYEPKKDTSEGCAVVGAGVQTYL |
| Interface Residues: | 109, 114, 118, 119, 120, 121, 122, 126, 160, 161, 163, 164, 167, 168, 171, 172, 175 |
| 3D-footprint Homologues: | 3a01_E, 1jgg_B, 2hos_A, 4cyc_A, 5hod_A, 3cmy_A, 1fjl_B, 5jlw_D, 3d1n_M, 2hdd_A, 2r5y_A, 1puf_B, 1ig7_A, 2lkx_A, 2ld5_A, 2h1k_B, 1e3o_C, 1nk2_P, 1du0_A, 5flv_I, 2d5v_B, 6fqp_B, 1o4x_A, 1k61_B, 6fqq_E, 4xrm_B, 1puf_A, 1mnm_C, 1b72_A, 7psx_B, 4xrs_G, 5zjt_E, 3rkq_B |
| Binding Motifs: | PH0082.1 wwdrTACATGTAarwkw |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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