Transcription Factor
| Accessions: | ERF4 (Athamap 20091028), T000642_1.02 (CISBP 1.02), O80340 (JASPAR 2024), T15957 (AthalianaCistrome v4_May2016) |
| Names: | AtERF4, EREBP-4, ERF4, Ethylene-responsive element-binding factor 4, Ethylene-responsive transcription factor 4, Protein RELATED TO APETALA2 5, ATERF-4, T000642_1.02;, ERF78_ARATH, AT3G15210, T15957; |
| Organisms: | Arabidopsis thaliana |
| Libraries: | Athamap 20091028 1, CISBP 1.02 2, JASPAR 2024 3, AthalianaCistrome v4_May2016 4 1 Bulow L, Engelmann S, Schindler M, Hehl R. AthaMap, integrating transcriptional and post-transcriptional data. Nucleic acids research 37:D983-6 (2009). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] 4 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed] |
| Uniprot: | O80340 |
| Notes: | experiment type:PBM, family:AP2, ecotype:Col-0, experiment type: ampDAP-seq, experiment type: ampDAP-seq (methyl-cytosines removed by PCR), experiment type: DAP-seq, family:AP2-EREBP |
| Length: | 222 |
| Pfam Domains: | 24-73 AP2 domain |
| Sequence: (in bold interface residues) | 1 MAKMGLKPDPATTNQTHNNAKEIRYRGVRKRPWGRYAAEIRDPGKKTRVWLGTFDTAEEA 60 61 ARAYDTAARDFRGAKAKTNFPTFLELSDQKVPTGFARSPSQSSTLDCASPPTLVVPSATA 120 121 GNVPPQLELSLGGGGGGSCYQIPMSRPVYFLDLMGIGNVGRGQPPPVTSAFRSPVVHVAT 180 181 KMACGAQSDSDSSSVVDFEGGMEKRSQLLDLDLNLPPPSEQA |
| Interface Residues: | 29, 31, 32, 33, 37, 39, 41, 46, 48, 50 |
| 3D-footprint Homologues: | 7wq5_A, 1gcc_A, 5wx9_A, 7et4_D |
| Binding Motifs: | ERF4 TAAGAGCCGCCACT M0022_1.02 cCGCCGcC MA0992.1 cCGCCGcC M0033 rrwwayGRCGGCGgmgrwrr M0047 yCkCCGCCGCCryhw MA0992.2 kcCGCCGyCAyh MA0992.3 cCGCCGyCA |
| Binding Sites: | ERF4_1 ERF4_6 ERF4_2 ERF4_3 ERF4_4 ERF4_5 MA0992.1.1 MA0992.1.10 MA0992.1.11 MA0992.1.12 MA0992.1.13 MA0992.1.14 MA0992.1.15 MA0992.1.16 MA0992.1.17 MA0992.1.18 MA0992.1.19 MA0992.1.2 MA0992.1.20 MA0992.1.3 MA0992.1.4 MA0992.1.5 MA0992.1.6 MA0992.1.7 MA0992.1.8 MA0992.1.9 MA0992.2.1 / MA0992.2.12 / MA0992.2.19 MA0992.2.10 MA0992.2.11 MA0992.2.12 MA0992.2.13 / MA0992.2.7 MA0992.2.14 / MA0992.2.8 MA0992.2.15 MA0992.2.16 / MA0992.2.9 MA0992.2.17 MA0992.2.10 / MA0992.2.18 MA0992.2.2 MA0992.2.20 MA0992.2.3 MA0992.2.4 MA0992.2.5 MA0992.2.4 / MA0992.2.6 MA0992.2.5 / MA0992.2.7 MA0992.2.6 / MA0992.2.8 MA0992.2.9 MA0992.2.11 MA0992.2.13 MA0992.2.14 MA0992.2.15 / MA0992.2.17 MA0992.2.16 MA0992.2.18 MA0992.2.19 MA0992.2.20 MA0992.3.1 / MA0992.3.12 / MA0992.3.13 / MA0992.3.15 / MA0992.3.17 MA0992.3.10 MA0992.3.11 MA0992.3.14 / MA0992.3.7 / MA0992.3.8 MA0992.3.16 / MA0992.3.9 MA0992.3.18 MA0992.3.19 MA0992.3.2 MA0992.3.20 MA0992.3.3 MA0992.3.4 MA0992.3.5 MA0992.3.6 |
| Publications: | Fujimoto SY, Ohta M, Usui A, Shinshi H, Ohme-Takagi M. 2000. Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. Plant Cell. 12:393-404. [Pubmed] Hao D., Ohme-Takagi M., Sarai A. Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant. J. Biol. Chem. 273:26857-26861 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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