Transcription Factor
| Accessions: | T100215_1.02 (CISBP 1.02), UP00308A (UniPROBE 20160601), P41817 (JASPAR 2024) |
| Names: | CUP9, T100215_1.02;, Homeobox protein CUP9, YPL177C, CUP9_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p an... |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 306 |
| Pfam Domains: | 166-219 Homeobox domain 180-219 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MNYNCEIQNRNSKNVDNQVSLPPIQVLFNSIEKRSMPELAFSNIEYSHGNLRSSTEEQNY 60 61 PAPVLLPQHHSIAYPAINSGGTSTTATPTASTVETSKTSSSAMDTQSQYGSSKKSKSASD 120 121 DAKPCYKSAPIYEIINKEKDAGAQYNRPFSDFVESKSRRKQNSGRRSNLPKETVQILNTW 180 181 LLNHLNNPYPTQQEKRELLIKTGLTKIQLSNWFINVRRRKIFSDYYTLVNSIPNDNANNT 240 241 PVERVQNVSAYHNTLSATNNTMYDATSTCSTDYELSKRFAHAPVTRRKKLIDRLEELKKL 300 301 SNPDMN |
| Interface Residues: | 165, 166, 167, 168, 210, 211, 214, 215, 216, 218, 219 |
| 3D-footprint Homologues: | 1mnm_C, 6fqp_B, 1puf_B, 1k61_B, 1le8_B, 1le8_A, 4xrs_G, 2lkx_A, 3lnq_A, 6fqq_E, 2hdd_A, 4xrm_B, 1du0_A, 2hos_A |
| Binding Motifs: | UP00308A_1 kwvywwATGTGTCAhwtwyh M1140_1.02 TGACAcaw MA0288.1 TGACAyAww |
| Binding Sites: | TGACGTCA AAGTGTCA AATGTGTC AGACACAT ATATGTCA ATCTGTCA ATGACACA ATGTGACA ATGTGTCA ATTGTGTC GACACAAA GACACATA GTGACACA GTGTCACA TGACACAA TGACATAA TGTGTCAA ATGCGTCA ATGTGTCG GTGACATA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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