Transcription Factor

Accessions: Q63244 (JASPAR 2024)
Names: Forkhead box protein Q1, FOXQ1_RAT, Hepatocyte nuclear factor 3 forkhead homolog 1, HFH-1, HNF-3/forkhead-like protein 1
Organisms: Rattus norvegicus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q63244
Length: 399
Pfam Domains: 115-211 Fork head domain
Sequence:
(in bold interface residues)
1 MKLEVFAPRAAHGDKMGSDLEGAGSSDVPSPLSAAGDDSLGSDGDCAANSPAAGSGAGDL 60
61 EGGGGERNSSGGASTQDDPEVTDGSRTQASPVGPCAGSVGGGEGARSKPYTRRPKPPYSY 120
121 IALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDP 180
181 SRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSHRTTVSASGYGGGSPPGPAGTPQPAPT 240
241 AGSSPIARSPARQEEGSSPASKFSSSFAIDSILSKPFRSRRDGTPALGVQLPWSAAPCPP 300
301 LRAYPALLPASSGGALLPLCAYGAAEPTLLASRGAEVQPAAPLFVAPLSTAAPAKPFRGP 360
361 ETAGAAHLYCPLRLPTALQAAAACGPGPHLSYRVETLLA
Interface Residues: 108, 110, 112, 155, 158, 160, 161, 162, 164, 165, 166, 168, 169, 178, 186, 211
3D-footprint Homologues: 7yz7_A, 7yzb_A, 7yzg_A, 3l2c_A, 7vox_H, 2hdc_A, 7tdx_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7tdw_A, 3g73_A, 6el8_A, 3qrf_G
Binding Motifs: MA0040.1 tAwTGTTTATw
MA0040.2 AwTGTTTATw
Binding Sites: MA0040.1.1
MA0040.1.10 / MA0040.1.8 / MA0040.1.9
MA0040.1.11
MA0040.1.12
MA0040.1.13 / MA0040.1.14
MA0040.1.15
MA0040.1.16
MA0040.1.17
MA0040.1.18
MA0040.1.2
MA0040.1.3
MA0040.1.4
MA0040.1.5 / MA0040.1.6
MA0040.1.7
MA0040.2.1
MA0040.2.10 / MA0040.2.11 / MA0040.2.8 / MA0040.2.9
MA0040.2.12
MA0040.2.13 / MA0040.2.14
MA0040.2.15
MA0040.2.16
MA0040.2.17
MA0040.2.18
MA0040.2.2
MA0040.2.3
MA0040.2.4
MA0040.2.5 / MA0040.2.6
MA0040.2.7
Publications: Overdier D. G., Porcella A., Costa R. H. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:2755-2766 (1994). [Pubmed]
Related annotations: PaperBLAST

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