Transcription Factor
| Accessions: | MTF1_HUMAN (HOCOMOCO 10), Q14872 (JASPAR 2024) |
| Names: | Metal regulatory transcription factor 1, MRE-binding transcription factor, MTF1_HUMAN, Transcription factor MTF-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q14872 |
| Length: | 753 |
| Pfam Domains: | 140-164 C2H2-type zinc finger 140-164 Zinc finger, C2H2 type 156-183 Zinc-finger double domain 170-194 C2H2-type zinc finger 170-194 Zinc finger, C2H2 type 186-213 Zinc-finger double domain 200-224 C2H2-type zinc finger 200-224 Zinc finger, C2H2 type 217-242 Zinc-finger double domain 229-253 Zinc finger, C2H2 type 229-253 C2H2-type zinc finger 245-271 Zinc-finger double domain 259-283 Zinc finger, C2H2 type 259-283 C2H2-type zinc finger 275-302 Zinc-finger double domain 289-313 Zinc finger, C2H2 type 291-313 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MGEHSPDNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLED 60 61 EDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEG 120 121 ATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKA 180 181 FLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYF 240 241 TTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTF 300 301 STQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNHSLCLSDLSLLSTDSELRENSSTTQGQ 360 361 DLSTISPAIIFESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSASLSLP 420 421 LVLQPGLSEPPQPLLPASAPSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAA 480 481 NHQEFLPHPQAPQPIVPGLSVVAGASASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLGA 540 541 NSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEKVFF 600 601 TTAVPVASSPGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERASSRRKGCSSPPPPE 660 661 PSPQAPDGPSLQLPAQTFSSAPVPGSSSSTLPSSCEQSRQAETPSDPQTETLSAMDVSEF 720 721 LSLQSLDTPSNLIPIEALLQGEEEMGLTSSFSK |
| Interface Residues: | 153, 155, 156, 159, 182, 183, 184, 185, 186, 188, 189, 191, 192, 193, 195, 208, 210, 211, 213, 214, 215, 216, 219, 220, 221, 223, 241, 242, 243, 244, 245, 247, 248, 252, 271, 272, 273, 274, 275, 277, 278, 279, 282, 301, 302, 303, 304, 305, 306, 307, 308, 309, 312, 316 |
| 3D-footprint Homologues: | 6wmi_A, 7w1m_H, 5und_A, 8ssu_A, 5v3j_F, 2i13_A, 8ssq_A, 6jnm_A, 5kkq_D, 1tf6_A, 5ei9_F, 2kmk_A, 6e94_A, 5yel_A, 6a57_A, 2jpa_A, 5k5i_A, 1mey_C, 2gli_A, 6ml4_A, 7eyi_G, 7ysf_A, 1ubd_C, 8cuc_F, 1tf3_A, 7y3l_A, 7n5w_A, 6u9q_A, 7txc_E, 5kl3_A, 1f2i_J, 4x9j_A, 8gn3_A, 1g2f_F, 6blw_A, 8h9h_G, 7y3m_I, 2lt7_A, 3uk3_C, 2wbs_A, 1llm_D, 5k5l_F, 4m9v_C, 5yj3_D |
| Binding Motifs: | MA0863.1 TTTGCACACGgCAC MTF1_HUMAN.H10MO.C|M01338 mGkgcCGTGYGCAamrs |
| Publications: | Solomon D. L. C., Amati B., Land H. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21:5372-5376 (1993). [Pubmed] Wang Y., Lorenzi I., Georgiev O., Schaffner W. Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration.. Biol. Chem. 385:623-632 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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