Transcription Factor
| Accessions: | T049425_1.02 (CISBP 1.02), Q52KP6 (JASPAR 2024) |
| Names: | T049425_1.02;, Zfp128, Zinc finger protein 128, Zinc finger protein 8, ZNF8_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 572 |
| Pfam Domains: | 25-65 KRAB box 253-274 C2H2-type zinc finger 254-276 C2H2-type zinc finger 254-276 Zinc finger, C2H2 type 268-292 Zinc-finger double domain 282-304 Zinc finger, C2H2 type 283-304 C2H2-type zinc finger 284-300 C2H2-type zinc finger 296-319 Zinc-finger double domain 309-330 C2H2-type zinc finger 310-332 Zinc finger, C2H2 type 324-348 Zinc-finger double domain 337-360 C2H2-type zinc finger 338-360 C2H2-type zinc finger 338-360 Zinc finger, C2H2 type 353-377 Zinc-finger double domain 365-386 C2H2-type zinc finger 366-388 Zinc finger, C2H2 type 366-388 C2H2-type zinc finger 384-405 Zinc-finger double domain 393-416 C2H2-type zinc finger 394-416 Zinc finger, C2H2 type 394-416 C2H2-type zinc finger 408-425 Zinc-finger double domain 464-486 Zinc finger, C2H2 type 464-486 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MDHQDKAATVAMASRPQATQLQEPVTFRDVAVDFTQEEWGQLDPTQRTLYRDVMLETFGH 60 61 LLSVGPDLPKPAVISQLEQGAELWVADRGGTGACHPGWILEPEDHTLLKDQGLPKMEPSP 120 121 ITEKDGFAKAVPCRSMIGIDQESDGQRQALKKDQSNLNDPKEIPLQSQSHKSLGLVEACV 180 181 LGLNTYLLPDISGREYGCTYDSQVKNSEHNPSLVRQRTDSPATQSFDDNGSQKAFDQIMP 240 241 ITELTKSQVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFSQNSSLVQH 300 301 ERIHTGDKPYKCDECGKSFCHSTHLTVHRRIHTGEKPYECQDCGRAFNQNSSLGRHKRTH 360 361 TGEKPYTCSVCGKSFSRTTCLFLHLRTHTEERPYECNHCGKGFRHSSSLAQHQRKHAGEK 420 421 PYECRQRLIFEQAPALIKYEWTEPLGCDSPLSQGERTQRSDRPFKCNQCGKCFTQSSHLI 480 481 RHQLTHSREEEPLRGRSRRQEQPCRRGSRLIQNTNSNSRELPVAQPKAGQASRTLALFDL 540 541 REIMQEQNPVHVIGVEEPSVGNSMLFDTRESR |
| Interface Residues: | 254, 264, 265, 266, 267, 268, 270, 271, 273, 274, 277, 292, 293, 294, 295, 296, 298, 299, 300, 303, 320, 321, 322, 323, 324, 325, 326, 327, 328, 348, 349, 350, 351, 352, 353, 354, 355, 358, 376, 377, 378, 379, 380, 382, 383, 387, 405, 406, 407, 408, 411, 414, 448, 449, 450, 453, 459, 473, 475, 477, 478, 481, 485 |
| 3D-footprint Homologues: | 2kmk_A, 3uk3_C, 1tf3_A, 7w1m_H, 5yel_A, 5ei9_F, 1mey_C, 6wmi_A, 2i13_A, 6e94_A, 2jpa_A, 6jnm_A, 5v3j_F, 4x9j_A, 5kkq_D, 8ssu_A, 8gn3_A, 7txc_E, 5yj3_D, 2gli_A, 8ssq_A, 1tf6_A, 6ml4_A, 4m9v_C, 7eyi_G, 7ysf_A, 6a57_A, 1ubd_C, 8cuc_F, 6blw_A, 6u9q_A, 5kl3_A, 5und_A, 1g2f_F, 2lt7_A, 7n5w_A, 7y3l_A, 1llm_D, 2wbs_A, 2drp_D, 1f2i_J, 5k5i_A, 8h9h_G, 8gh6_A, 7y3m_I, 5k5l_F |
| Binding Motifs: | PB0094.1 khwdkGGCGTACccyaa PB0198.1 kkTATAywTATAmc M0438_1.02 GgCGTACs |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.