Transcription Factor

Accessions: T093277_1.02 (CISBP 1.02), P58304 (JASPAR 2024)
Names: T093277_1.02;, VSX2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10, Visual system homeobox 2, VSX2_HUMAN
Organisms: Homo sapiens
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: family:Homeodomain
Length: 361
Pfam Domains: 149-205 Homeobox domain
300-318 OAR domain
Sequence:
(in bold interface residues)
1 MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGH 60
61 LLAARSVLSPAGVGGMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQT 120
121 ASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREM 180
181 LAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSA 240
241 KDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKMEQDERGPDAQAAISQEE 300
301 LRENSIAVLRAKAQEHSTKVLGTVSGPDSLARSTEKPEEEEAMDEDRPAERLSPPQLEDM 360
361 A
Interface Residues: 118, 119, 120, 123, 124, 130, 134, 148, 149, 150, 151, 152, 190, 191, 193, 194, 197, 198, 201, 202, 205
3D-footprint Homologues: 1e3o_C, 1au7_A, 1o4x_A, 4j19_B, 1puf_B, 3d1n_M, 5zfz_A, 1fjl_B, 2h1k_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 6es3_K, 2ld5_A, 7q3o_C, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 5flv_I, 3l1p_A, 1b72_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 7xrc_C, 2xsd_C, 8g87_X, 1du0_A, 4qtr_D
Binding Motifs: MA0726.1 yTAATTAg
M3059_1.02 dgsTAATTAGCbmw
MA0726.2 yTAATTA
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

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