Transcription Factor
Accessions: | T093277_1.02 (CISBP 1.02), P58304 (JASPAR 2024) |
Names: | T093277_1.02;, VSX2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10, Visual system homeobox 2, VSX2_HUMAN |
Organisms: | Homo sapiens |
Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Notes: | family:Homeodomain |
Length: | 361 |
Pfam Domains: | 149-205 Homeobox domain 300-318 OAR domain |
Sequence: (in bold interface residues) | 1 MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGH 60 61 LLAARSVLSPAGVGGMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQT 120 121 ASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREM 180 181 LAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSA 240 241 KDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKMEQDERGPDAQAAISQEE 300 301 LRENSIAVLRAKAQEHSTKVLGTVSGPDSLARSTEKPEEEEAMDEDRPAERLSPPQLEDM 360 361 A |
Interface Residues: | 118, 119, 120, 123, 124, 130, 134, 148, 149, 150, 151, 152, 190, 191, 193, 194, 197, 198, 201, 202, 205 |
3D-footprint Homologues: | 1e3o_C, 1au7_A, 1o4x_A, 4j19_B, 1puf_B, 3d1n_M, 5zfz_A, 1fjl_B, 2h1k_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 6es3_K, 2ld5_A, 7q3o_C, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 5flv_I, 3l1p_A, 1b72_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 7xrc_C, 2xsd_C, 8g87_X, 1du0_A, 4qtr_D |
Binding Motifs: | MA0726.1 yTAATTAg M3059_1.02 dgsTAATTAGCbmw MA0726.2 yTAATTA |
Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.