Transcription Factor
| Accessions: | CcpA (DBTBS 1.0), 1rzr_A (3D-footprint 20231221), 1rzr_C (3D-footprint 20231221), 1rzr_D (3D-footprint 20231221), 1rzr_G (3D-footprint 20231221) |
| Names: | Catabolite control protein A, CcpA, CCPA_BACME, Glucose-resistance amylase regulator |
| Organisms: | Bacillus subtilis, Bacillus megaterium |
| Libraries: | DBTBS 1.0 1, 3D-footprint 20231221 2 1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed] 2 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P46828 |
| Length: | 332 |
| Pfam Domains: | 4-49 Bacterial regulatory proteins, lacI family 61-322 Periplasmic binding proteins and sugar binding domain of LacI family 63-312 Periplasmic binding protein domain 169-331 Periplasmic binding protein-like domain |
| Sequence: (in bold interface residues) | 1 MNVTIYDVAREASVSMATVSRVVNGNPNVKPSTRKKVLETIERLGYRPNAVARGLASKKT 60 61 TTVGVIIPDISNIFYAELARGIEDIATMYKYNIILSNSDQNQDKELHLLNNMLGKQVDGI 120 121 IFMSGNVTEEHVEELKKSPVPVVLAASIESTNQIPSVTIDYEQAAFDAVQSLIDSGHKNI 180 181 AFVSGTLEEPINHAKKVKGYKRALTESGLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKP 240 241 TAIFVGTDEMALGVIHGAQDRGLNVPNDLEIIGFDNTRLSTMVRPQLTSVVQPMYDIGAV 300 301 AMRLLTKYMNKETVDSSIVQLPHRIEFRQSTK |
| Interface Residues: | 5, 6, 15, 16, 17, 18, 20, 21, 27, 28, 29, 52, 55, 56 |
| 3D-footprint Homologues: | 1efa_B, 3oqm_C, 7ce1_D, 1l1m_B, 1zvv_A, 1jft_A |
| Binding Motifs: | CcpA TGwAARCGbTwtC 1rzr_AD TGTnAGCGCTnTCA 1rzr_C CGCTnACA 1rzr_CG TGTnAGCGCTTTCA |
| Binding Sites: | ackA_1 ackA_2 acoA_2 acoR acsA_1 acuA_1 amyE_1 araA_3 araB araE_3 bglP_1 bglS_1 ccpC_1 citM_1 citZ_1 cydA_1 dctP_1 dra_1 galT glpF_1 gntR_1 hutP_2 hutP_3 ilvB_1 iolB kdgA lcfA levD_1 licB_1 malA_1 mmgA_1 mmsA_1 msmX phoP_1 pta_1 pta_2 rbsR_3 sigL treP_1 uxaC_1 xylA_1 xynP_1 ydhO yobO yxjC_1 yxkJ 1rzr_B / 1rzr_R 1rzr_E / 1rzr_H |
| Publications: | Schumacher M.A, Allen G.S, Diel M, Seidel G, Hillen W, Brennan R.G. Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell 118:731-41 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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