Transcription Factor

						

			
Accessions: O88609 (JASPAR 2024)

			
Names: LIM homeobox transcription factor 1-beta, LIM/homeobox protein 1.2, LIM/homeobox protein LMX1B, LMX-1.2, LMX1B_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O88609
Length: 395
Pfam Domains:    56-111 LIM domain
  115-172 LIM domain
  220-276 Homeobox domain
  244-272 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ   60
  61 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME  120
 121 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS  180
 181 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV  240
 241 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS  300
 301 RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTSLTS  360
 361 LSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
Interface Residues: 220, 221, 222, 223, 261, 262, 264, 265, 268, 269, 272, 273, 276, 279, 280, 286, 289, 303
3D-footprint Homologues: 1puf_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_B, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 3l1p_A, 2hos_A, 3a01_E, 2d5v_B, 7psx_B, 5hod_A, 1au7_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1b72_A, 4cyc_A, 2r5y_A, 5flv_I, 1e3o_C, 1le8_A, 7xrc_C, 1o4x_A, 8g87_X, 1du0_A, 5zjt_E, 4qtr_D, 4xrm_B
Binding Motifs: PH0101.1 rrwwwTTAATTAAtwyb
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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