Transcription Factor

Accessions: ELK1_full (HumanTF 1.0), ELK1_Full (HumanTF2 1.0)
Names: ELK1, ELK1_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P19419
Notes: Ensembl ID: ENSG00000126767; Full protein sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000126767; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: ETS; Clone source: Jolma et al. 2013
Length: 429
Pfam Domains: 5-87 Ets-domain
Sequence:
(in bold interface residues)
1 MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL 60
61 SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIH 120
121 AAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVV 180
181 LPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGL 240
241 GRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGH 300
301 AASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTH 360
361 TLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVV 420
421 LSPGPQKP*
Interface Residues: 58, 59, 61, 62, 63, 65, 66, 80
3D-footprint Homologues: 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A
Binding Motifs: ELK1_full_1 ACCGGAAGTr
ELK1_full_2 cACTTCCGsCGGAAgyg
E2F1_ELK1_1 sGCGssyrAmCGGAAGt
E2F1_ELK1_2 sGCGcshwtwkggrsCGGAAGt
E2F1_ELK1_2_3 sGCGcsywdkkkrrrsCGGAAGT
ELK1_EOMES_1 rrGyGygrrrryrgkrtsrCrCCGGAAgy
ELK1_EOMES_2 rcCGGAAGTrgGyGygA
ELK1_EOMES_2_3 tmrCACCGGAAgy
ELK1_ETV7 amsCGGAMGGATdTCCGgyt
ELK1_EVX1 rsCGGwAATgrymATTA
ELK1_FOXI1_1 AsCGGAArTrTmAACAk
ELK1_FOXI1_2 rCCGGAAGsWmArCAk
ELK1_FOXI1_2_3 rmCGGAAGTTkw
ELK1_FOXI1_2_3_4 wGyTkmCGGAwGTk
ELK1_FOXI1_2_3_4_5 ammGGAAayrTAAAyA
ELK1_FOXI1_2_3_4_5_6 ammGGAAbrtAAACA
ELK1_HOXA1_1 aCCGGAAGTAAtTa
ELK1_HOXA1_2 rCCGGAAGTvaTya
ELK1_HOXA3_1 aCCGGwAAtkrkwyywcycATTAc
ELK1_HOXA3_2 rcCGGwAAtkr-
ELK1_HOXB13_1 rCCGGAAGThrTAAAa
ELK1_HOXB13_2 rvCGGAArywrTwAaa
ELK1_ONECUT2_1 rCCGGAAscGATCGATam
ELK1_ONECUT2_2 rsCGGAAscGATCGATa
ELK1_PAX1 aCCGGAACyACGCwTsRsYg
ELK1_PAX5 aCCGGAACyACGCwYsAsyg
ELK1_PAX9 rCCGGAACyACGCwysAmTk
ELK1_SPDEF mcmGGAmGGAwATCCKgg
ELK1_SREBF2_1 rcCGGAAGTsrCGTGA
ELK1_SREBF2_2 rtCrCGTGACCGGAAGy
ELK1_TBX21_1 aaGGtGtgrmrkkkmkttmrCrcCGGAAGyg
ELK1_TBX21_2 tcrCACCGGAAgyr
ELK1_TBX21_2_3 agGTGykAaawwwwwtTmaCACMGGAart
ELK1_TBX21_2_3_4 TmaCACmGGAwvhg
ELK1_TEF rcCGGAaGTKACGTAAb
FOXO1_ELK1_1 rsCGGAwGTTdtk
FOXO1_ELK1_2 rwmAACAGGAAGtr
FOXO1_ELK1_2_3 tgttgcCGGAAGt
GCM1_ELK1_1 ATryGGGCGGAAmCGGAwsta
GCM1_ELK1_2 rtGcGGGCGGAAGkg
GCM1_ELK1_2_3 rtGcGGGCGGAAGkg
GCM2_ELK1 rTryGGGCGGAAGTr
HOXB13_ELK1 rcmGGAAGycrTAAAm
HOXB2_ELK1_1 rcCGGAAGTmrTTA
HOXB2_ELK1_2 TAATkrCCGGAAGTr
HOXD12_ELK1_1 rrsCGGAAGTyGTAAAa
HOXD12_ELK1_2 rsCGGAAGTmrTAAAA
POU2F1_ELK1_1 aCCGGAwATGCAw
POU2F1_ELK1_2 mCCGsATATGCAm
TEAD4_ELK1_1 ACCGGAhrTCCGGwATGh
TEAD4_ELK1_2 rGAATsCGGAAGyg
TEAD4_ELK1_2_3 rmATwCCGGAwgT
TEAD4_ELK1_2_3_4 GGAATsCGGAAGtk
TFAP2C_ELK1 yGCCksrGGsgrCGGAAGyg
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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