Transcription Factor
| Accessions: | T095152_1.02 (CISBP 1.02), HNF1A_MOUSE (HOCOMOCO 10), P22361 (JASPAR 2024) |
| Names: | Hnf1a, T095152_1.02;, Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, HNF1A_MOUSE, LFB1, Liver-specific transcription factor LF-B1, TCF-1, Transcription factor 1 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 628 |
| Pfam Domains: | 1-176 Hepatocyte nuclear factor 1 (HNF-1), N terminus 200-273 Homeobox domain 282-539 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus 540-627 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus |
| Sequence: (in bold interface residues) | 1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTEL 60 61 PNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVK 120 121 SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA 180 181 GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE 240 241 CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP 300 301 AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSS 360 361 LLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPAS 420 421 LGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ 480 481 SHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQV 540 541 FTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSD 600 601 SNGHSHLLPSNHSVIETFISTQMASSSQ |
| Interface Residues: | 140, 141, 142, 143, 145, 146, 152, 153, 200, 201, 203, 263, 264, 265, 266, 269, 270, 273 |
| 3D-footprint Homologues: | 2h8r_B, 1ic8_B, 1fjl_B, 5zfz_A, 3cmy_A, 2lkx_A, 4j19_B, 1puf_B, 1le8_A |
| Binding Motifs: | M0973_1.02 yTAACydr HNF1A_MOUSE.H10MO.A|M01145 rGTTAATawTTamcm MA1991.1 bbcCTTTGATstbk MA1991.2 cCTTTGATst |
| Binding Sites: | MA1991.1.1 MA1991.1.10 / MA1991.1.19 MA1991.1.11 / MA1991.1.20 MA1991.1.12 MA1991.1.13 MA1991.1.14 MA1991.1.15 MA1991.1.16 MA1991.1.17 MA1991.1.18 MA1991.1.19 MA1991.1.2 MA1991.1.20 MA1991.1.3 / MA1991.1.6 MA1991.1.4 / MA1991.1.7 MA1991.1.5 / MA1991.1.8 MA1991.1.12 / MA1991.1.6 MA1991.1.16 / MA1991.1.7 MA1991.1.17 / MA1991.1.8 MA1991.1.18 / MA1991.1.9 MA1991.1.10 MA1991.1.11 MA1991.1.13 MA1991.1.14 MA1991.1.15 MA1991.1.3 MA1991.1.4 MA1991.1.5 MA1991.1.9 MA1991.2.1 MA1991.2.10 MA1991.2.11 MA1991.2.12 MA1991.2.13 MA1991.2.14 MA1991.2.15 / MA1991.2.19 MA1991.2.16 / MA1991.2.7 MA1991.2.17 MA1991.2.18 MA1991.2.2 MA1991.2.20 MA1991.2.3 MA1991.2.4 MA1991.2.5 MA1991.2.6 MA1991.2.8 MA1991.2.9 |
| Publications: | Emmanuel AO, Arnovitz S, Haghi L, Mathur PS, Mondal S, Quandt J, Okoreeh MK, Maienschein-Cline M, Khazaie K, Dose M, Gounari F. TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4(+)CD8(+) thymocytes. Nat Immunol 19:1366-1378 (2018). [Pubmed] |
| Related annotations: | PaperBLAST |
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