Transcription Factor

Accessions: T012791_1.02 (CISBP 1.02), Q18053 (JASPAR 2024)
Names: hlh-26, T012791_1.02;, HLH26_CAEEL
Organisms: Caenorhabditis elegans
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:bHLH
Length: 210
Pfam Domains: 20-65 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MSSSPTSSSSGSPSSHGHRSETEKQRRDDTNDLLNEFKKIVQKSESEKLSKEEVLFRIVK 60
61 LLSGIQLHHESFSTSPGPIRSIKKIKSDREQVRRNKRVAAYRELRKFIALNNLSSSEEID 120
121 KMENLKVLEIIFEVIRGKSITCTVPCLPFPILPFLPVFPVYSPLVFNSYNQFSLYPPHMP 180
181 TVQIPIVPSSSFEIDALEIEENEKDIDIVG
Interface Residues: 20, 22, 23, 26, 27
3D-footprint Homologues: 4h10_A, 8osl_P
Binding Motifs: PL0009.1 tawgrCACGTGTCywaw
M0171_1.02 rACACGTGy
UN0705.1 rACACGTGy
Publications: Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed]
Related annotations: PaperBLAST

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