Transcription Factor
| Accessions: | UP00099A (UniPROBE 20160601), O35885 (JASPAR 2024) |
| Names: | 2410083I15Rik, achaete-scute complex homolog-like 2 (Drosophila), Achaete-scute homolog 2, Ascl2, Mash-2, Mash2, ASCL2_MOUSE, ASH-2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | achaete-scute complex homolog-like 2 (Drosophila) |
| Length: | 263 |
| Pfam Domains: | 122-171 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MEAHLDWYGVPGLQEASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCAAPELVAG 60 61 AQGLNASLMDGGALPRLMPTSSGVAGACAARRRQASPELLRCSRRRRSGATEASSSSAAV 120 121 ARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAV 180 181 RAALAGGLLTPATPPSDECAQPSASPASASLSCASTSPSPDRLGCSEPTSPRSAYSSEES 240 241 SCEGELSPMEQELLDFSSWLGGY |
| Interface Residues: | 123, 124, 126, 127, 128, 130, 131 |
| 3D-footprint Homologues: | 2ypa_A, 2ypa_B, 2ql2_D, 5i50_B, 6od3_F, 7z5k_B, 5gnj_I |
| Binding Motifs: | PB0003.1 ytyarCAGCTGCtvytk PB0107.1 bymwcCCcryccyrty UP00099A_1 ytyarCAGCTGCtvytk MA0816.1 arCAGCTGyy UP00099A_2 bymwcCCcryccyrty |
| Binding Sites: | AACAGCTG AACAGGTG ACACCTGC ACAGCTGC ACAGCTGG ACAGCTGT ACAGGTGC AGCAGCTG AGCAGGTG CACCTGCA CACCTGCC CAGCTGCA CAGCTGCC CAGCTGCG CAGCTGTA CAGCTGTC CCACCTGC CCAGCTGC GCACCTGC GCAGCTGC |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.