Transcription Factor

Accessions: SMAD3_HUMAN (HOCOMOCO 10), SMAD3_MOUSE (HOCOMOCO 10), P84022 (JASPAR 2024), Q8BUN5 (JASPAR 2024)
Names: hMAD-3, hSMAD3, JV15-2, MAD homolog 3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3, SMAD3_HUMAN, mMad3, SMAD3_MOUSE
Organisms: Homo sapiens, Sus scrofa, Sus scrofa domesticus, Rattus norvegicus, Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 425
Pfam Domains: 31-131 MH1 domain
227-402 MH2 domain
288-363 Interferon-regulatory factor 3
Sequence:
(in bold interface residues)
1 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV 60
61 NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV 120
121 CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP 180
181 PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL 240
241 NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG 300
301 GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF 360
361 EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR 420
421 CSSVS
Interface Residues: 72, 74, 76, 81, 302
3D-footprint Homologues: 6fzs_A, 5nm9_A, 6h3r_A, 5od6_A, 5mey_A, 6fwr_A
Binding Motifs: PB0060.1 mdwatCCAGACrkbasm
PB0164.1 kmmgcCCCGCCacyyyb
MA0795.1 yGTCTAGACA
SMAD3_HUMAN.H10MO.C|M01503 / SMAD3_MOUSE.H10MO.C|M01336 gtGTCTGgcy
MA1622.1 rtkrTGACTCAtwm
Binding Sites: MA1622.1.1
MA1622.1.10
MA1622.1.11
MA1622.1.12
MA1622.1.13
MA1622.1.14
MA1622.1.15
MA1622.1.16
MA1622.1.17
MA1622.1.18
MA1622.1.19
MA1622.1.2
MA1622.1.20
MA1622.1.3 / MA1622.1.5
MA1622.1.4 / MA1622.1.6
MA1622.1.7
MA1622.1.8
MA1622.1.9
Publications: Chen S, Kulik M, Lechleider RJ. Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta. Nucleic Acids Res 31:1302-10 (2003). [Pubmed]

Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.