Transcription Factor

						

			
Accessions: P78424 (JASPAR 2024)

			
Names: PO6F2_HUMAN, POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF-1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P78424
Length: 691
Pfam Domains:   478-525 Pou domain - N-terminal to homeobox domain
  560-586 Pou domain - N-terminal to homeobox domain
  608-663 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MSALLQDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPS   60
  61 KLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLLTAQQLASAVAGVMPGGPPALNQP  120
 121 ILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQ  180
 181 QLQLQLQQQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTS  240
 241 QLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHGLPSPLTPPNPLQLVNNP  300
 301 LASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAA  360
 361 SGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSV  420
 421 GQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVN  480
 481 LEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQE  540
 541 NTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFI  600
 601 GSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQ  660
 661 ALKNTIKRLKQHEPATAVPLEPLTDSLEENS
Interface Residues: 502, 518, 519, 520, 521, 523, 524, 559, 560, 566, 570, 608, 609, 610, 611, 649, 650, 652, 653, 656, 657, 660, 661, 664
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 8g87_X, 1e3o_C, 1au7_A, 2xsd_C, 7xrc_C, 1o4x_A, 2h1k_B, 5zjt_E, 1puf_A, 6a8r_A, 1fjl_B, 1ig7_A, 5zfz_A, 6fqp_B, 3cmy_A, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 7q3o_C, 4cyc_A, 5jlw_D, 2ld5_A, 6es3_K, 3rkq_B, 2r5y_A, 5hod_A, 2hdd_A, 1puf_B, 1b72_A, 3a01_E, 4xrs_G, 1le8_A, 4qtr_D, 1du0_A
Binding Motifs: MA0793.1 asCTmATTAw
MA0793.2 asCTmATTA
			
Publications: Rhee J. M., Gruber C. A., Brodie T. B., Trieu M., Turner E. E. Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273:34196-34205 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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