Transcription Factor
| Accessions: | h (DrosophilaTF 1.1), P14003 (JASPAR 2024) |
| Names: | HAIR_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P14003 |
| Length: | 337 |
| Pfam Domains: | 32-89 Helix-loop-helix DNA-binding domain 105-142 Hairy Orange |
| Sequence: (in bold interface residues) | 1 MVTGVTAANMTNVLGTAVVPAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILD 60 61 ATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSR 120 121 FPGIEPAQRRRLLQHLSNCINGVKTELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQQGAA 180 181 APYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAV 240 241 AAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPPSPANSSYE 300 301 PMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW |
| Interface Residues: | 33, 35, 36, 37, 39, 40, 43, 44, 72 |
| 3D-footprint Homologues: | 7z5k_B, 1an4_A, 7d8t_A, 5eyo_A, 1am9_A, 6g1l_A, 4h10_A, 8osl_P |
| Binding Motifs: | MA0449.1 GgCrCGyGcC h svggCACGCGmcak |
| Binding Sites: | h_12a h_12b h_2 h_2-10 h_2-11 h_2-15 h_2-17 h_2-18 h_2-2 h_2-23 h_2-31 h_2-33 h_2-4 h_2-5 h_2-7 h_2-8 h_23 h_34 h_36 h_39 h_4 h_47 h_5 h_6 h_8 h_9 MA0449.1.1 / MA0449.1.14 / MA0449.1.8 MA0449.1.10 MA0449.1.11 MA0449.1.12 MA0449.1.13 MA0449.1.15 MA0449.1.16 MA0449.1.17 MA0449.1.18 MA0449.1.19 MA0449.1.2 MA0449.1.20 MA0449.1.3 MA0449.1.4 MA0449.1.5 MA0449.1.6 MA0449.1.7 MA0449.1.9 |
| Publications: | van Doren M., Bailey A. M., Esnayra J., Ede K., Posakony J. W. Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8:2729-2742 (1994). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.