Transcription Factor
| Accessions: | tin (DrosophilaTF 1.1), P22711 (JASPAR 2024) |
| Names: | Msh-2, Muscle-specific homeobox protein tinman, NK-4, TIN_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P22711 |
| Length: | 416 |
| Pfam Domains: | 302-358 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MLQHHQQQAQSGGYYDHYTQSPSPGSLTNADALNTTPFSVKDILNMVNQTEAYEGSYGHI 60 61 DGAATASALFAAGEYQNPHQYLNHQQHQQSELPIPQQQLHHQHLDDGATTSSSLSPLLPP 120 121 PPHQLYGGYQDYGMPAHMFQHHHGHPHQSFQHSASAYNMSASQFYAGASATAYQTPATYN 180 181 YNYAGSGEVYGGATPSAVGIKSEYIPTPYVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLS 240 241 QRLMETASNSSSLRSIYGSDEGAKKKDNSQVTSSRSELRKNSISGNSNPGSNSGSTKPRM 300 301 KRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKRGD 360 361 IDCEGIAKHLKLKSEPLDSPTSLPPPIPNHVMWPPTMQQSQQQQQHHAQQQQMQHM |
| Interface Residues: | 269, 270, 271, 274, 275, 281, 292, 300, 301, 302, 303, 304, 305, 343, 344, 346, 347, 350, 351, 354, 355, 358 |
| 3D-footprint Homologues: | 1o4x_A, 1e3o_C, 1mnm_C, 4j19_B, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 3d1n_M, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 6m3d_C, 1au7_A, 5flv_I, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1jgg_B, 4xrs_G, 2hos_A, 4cyc_A, 1le8_A, 7xrc_C, 2xsd_C, 1k61_B, 3l1p_A, 8g87_X, 4qtr_D, 1du0_A, 1puf_B |
| Binding Motifs: | MA0247.1 yTYAAGTG tin CACTTrA MA0247.2 wbTCrAGTGs MA0247.3 bTCrAGTGs |
| Binding Sites: | MA0247.1.1 MA0247.1.10 MA0247.1.11 MA0247.1.12 MA0247.1.13 MA0247.1.14 MA0247.1.15 MA0247.1.16 / MA0247.1.19 MA0247.1.17 / MA0247.1.20 MA0247.1.18 MA0247.1.2 MA0247.1.3 MA0247.1.4 MA0247.1.5 MA0247.1.6 MA0247.1.7 MA0247.1.8 MA0247.1.9 MA0247.2.1 MA0247.2.10 MA0247.2.11 MA0247.2.12 MA0247.2.13 MA0247.2.14 MA0247.2.15 MA0247.2.16 MA0247.2.17 MA0247.2.18 MA0247.2.19 MA0247.2.2 MA0247.2.20 MA0247.2.3 MA0247.2.4 MA0247.2.5 MA0247.2.6 MA0247.2.7 MA0247.2.8 MA0247.2.9 MA0247.3.1 MA0247.3.10 MA0247.3.11 MA0247.3.12 MA0247.3.13 MA0247.3.14 MA0247.3.15 MA0247.3.16 MA0247.3.17 MA0247.3.18 MA0247.3.19 MA0247.3.2 MA0247.3.20 MA0247.3.3 MA0247.3.4 MA0247.3.5 MA0247.3.6 MA0247.3.7 MA0247.3.8 MA0247.3.9 |
| Publications: | Kremser T, Gajewski K, Schulz R.A, Renkawitz-Pohl R. Tinman regulates the transcription of the beta3 tubulin gene (betaTub60D) in the dorsal vessel of Drosophila. Developmental biology 216:327-39 (1999). [Pubmed] Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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