Transcription Factor
Accessions: | T049107_1.02 (CISBP 1.02), Q62445 (JASPAR 2024) |
Names: | Sp4, T049107_1.02;, SP4_MOUSE |
Organisms: | Mus musculus |
Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | Q62445 |
Notes: | experiment type:PBM, family:C2H2 ZF |
Length: | 782 |
Pfam Domains: | 645-669 C2H2-type zinc finger 645-669 Zinc finger, C2H2 type 661-688 Zinc-finger double domain 675-699 Zinc finger, C2H2 type 675-699 C2H2-type zinc finger 692-714 Zinc-finger double domain 705-727 Zinc finger, C2H2 type 705-727 C2H2-type zinc finger |
Sequence: (in bold interface residues) | 1 MSDQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSHPSPLALLAATCSKIGTPG 60 61 ENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPAS 120 121 SSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQIN 180 181 PTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQ 240 241 LQTLPGTQAQVVTTLPINIGGVTLALPVINNVTAGGGTGQVGQPTTTTDSGTSNGNQLVS 300 301 TPTTSTAPASTMPESPSSSTTCTTTASTTLTSSDTLVSSADTGQYASTSASSSERTIEEP 360 361 QTPAATESEAQSSSQLQSNGIQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPP 420 421 QSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSN 480 481 LQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLG 540 541 AAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVH 600 601 LQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCGKVYGKTS 660 661 HLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHL 720 721 SKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNME 780 781 EF |
Interface Residues: | 632, 634, 635, 636, 637, 641, 657, 658, 659, 660, 661, 663, 664, 666, 667, 670, 687, 688, 689, 690, 691, 693, 694, 695, 698, 715, 716, 717, 718, 719, 720, 721, 722, 723, 726 |
3D-footprint Homologues: | 7eyi_G, 2i13_A, 7ysf_A, 5yel_A, 1tf3_A, 6ml4_A, 7n5w_A, 6jnm_A, 8cuc_F, 2kmk_A, 8ssu_A, 2gli_A, 8gn3_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 1llm_D, 5kl3_A, 1ubd_C, 5ei9_F, 8ssq_A, 1mey_C, 5und_A, 5k5i_A, 5v3j_F, 8h9h_G, 2lt7_A, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 2jpa_A, 7w1m_H, 7y3l_A, 3uk3_C, 7txc_E, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C, 5yj3_D |
Binding Motifs: | PB0076.1 kgymmCGCCCCCyysyc PB0180.1 ywwAGGCGTGkCyhd M0401_1.02 rkGGGCGkd |
Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.