Transcription Factor
| Accessions: | T144622_1.02 (CISBP 1.02), Q811W0 (JASPAR 2024) |
| Names: | Sox21, T144622_1.02;, SOX21_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Sox |
| Length: | 276 |
| Pfam Domains: | 8-76 HMG (high mobility group) box 9-71 Domain of unknown function (DUF1898) 77-95 SOX transcription factor |
| Sequence: (in bold interface residues) | 1 MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDE 60 61 AKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGSVADAEHPALKAGAGLHAG 120 121 AGGGLVPESLLANPEKAAAAAAAAAARVFFPQSAAAAAAAAAAAAAGSPYSLLDLGSKMA 180 181 EISSSSSGLPYASSLGYPTAGAGAFHGAAAAAAAAAAAAGGHTHSHPSPGNPGYMIPCNC 240 241 SAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYAAAL |
| Interface Residues: | 10, 13, 15, 16, 17, 19, 23, 27, 34, 35, 36, 39, 77, 81 |
| 3D-footprint Homologues: | 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 3tq6_B, 1hry_A, 1ckt_A, 7zie_A |
| Binding Motifs: | PB0069.1 hwtwATTATAATwdwk PB0173.1 vvycwATTGTtcckhkr M1599_1.02 aTTgttytb |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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