Transcription Factor

Accessions: BHLHB2_DBD (HumanTF 1.0)
Names: BHE40_HUMAN, BHLHB2, bHLHe40, Class B basic helix-loop-helix protein 2, Class E basic helix-loop-helix protein 40, DEC1, Differentially expressed in chondrocytes protein 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: O14503
Notes: Ensembl ID: ENSG00000134107; DNA-binding domain sequence; TF family: bHLH; Clone source: Megaman
Length: 114
Pfam Domains: 28-78 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 PAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG 60
61 HLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFC
Interface Residues: 27, 28, 29, 31, 32, 35, 36, 62
3D-footprint Homologues: 1an4_A, 7d8t_A, 5v0l_A, 4h10_A, 7f2f_B, 5eyo_A, 1a0a_B, 7xi3_A, 7rcu_E, 1am9_A, 6g1l_A, 4zpk_A, 7ssa_L, 5nj8_D, 8osl_P, 8osl_O, 7xhv_B, 4h10_B, 5nj8_C, 7xi3_B, 4zpr_B, 5v0l_B
Binding Motifs: BHLHB2_DBD vkCACGTGmc
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

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