Transcription Factor
| Accessions: | Q9H2A3 (JASPAR 2024) |
| Names: | bHLHa8, Class A basic helix-loop-helix protein 8, Neurogenin-2, NGN-2, NGN2_HUMAN, Protein atonal homolog 4 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9H2A3 |
| Length: | 272 |
| Pfam Domains: | 113-164 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAG 60 61 QGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNR 120 121 ERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGG 180 181 LPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSP 240 241 ASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI |
| Interface Residues: | 114, 117, 118, 120, 121, 122, 124, 125, 150 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D, 7ssa_L |
| Binding Motifs: | MA0669.1 raCATATGtY MA1642.1 rrraCAGATGGyv MA1642.2 CAGATGG |
| Binding Sites: | MA1642.1.7 / MA1642.1.9 MA1642.1.15 / MA1642.1.20 MA1642.1.11 / MA1642.1.16 MA1642.1.1 MA1642.1.10 / MA1642.1.8 MA1642.1.11 / MA1642.1.9 MA1642.1.10 / MA1642.1.12 MA1642.1.13 MA1642.1.14 MA1642.1.15 MA1642.1.12 / MA1642.1.17 MA1642.1.13 / MA1642.1.18 MA1642.1.19 MA1642.1.2 MA1642.1.3 MA1642.1.4 MA1642.1.5 MA1642.1.6 MA1642.1.7 MA1642.1.8 MA1642.1.14 MA1642.1.16 MA1642.1.17 MA1642.1.18 MA1642.1.19 MA1642.1.20 MA1642.2.10 / MA1642.2.11 / MA1642.2.12 / MA1642.2.15 / MA1642.2.17 / MA1642.2.18 / MA1642.2.2 / MA1642.2.20 / MA1642.2.3 / MA1642.2.5 / MA1642.2.6 / MA1642.2.7 / MA1642.2.8 MA1642.2.13 / MA1642.2.9 MA1642.2.16 MA1642.2.1 / MA1642.2.19 / MA1642.2.4 MA1642.2.14 |
| Publications: | Henke RM, Meredith DM, Borromeo MD, Savage TK, Johnson JE. Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Dev Biol 328:529-40 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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