Transcription Factor
| Accessions: | ETV1_DBD (HumanTF 1.0), ETV1_TF2 (HumanTF2 1.0) |
| Names: | ETS translocation variant 1, Ets-related protein 81, ETV1, ETV1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P50549 |
| Notes: | Ensembl ID: ENSG00000006468; DNA-binding domain sequence; TF family: ETS; Clone source: Megaman, Ensembl ID: ENSG00000006468; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 126 |
| Pfam Domains: | 22-103 Ets-domain |
| Sequence: (in bold interface residues) | 1 MAIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVAR 60 61 RWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPL 120 121 LKTDME |
| Interface Residues: | 62, 74, 75, 77, 78, 79, 81, 82, 96 |
| 3D-footprint Homologues: | 6sjf_B, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 8ee9_F, 4uno_A, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | ETV1_DBD aCCGGAWrtr FOXO1_ETV1 rsCGGAwGttkw GCM1_ETV1 rtrsGGGCGGAwGkk HOXB13_ETV1 rCCGGAAgTawwaAAa HOXB2_ETV1 rCCGGAAATgr- HOXD12_ETV1_1 rcCGGAAGTAATAAAm HOXD12_ETV1_2 rsCGGAAGTCRTAAAw POU2F1_ETV1 aCCGGATATGCAw TEAD4_ETV1 acCGGAAaTrcc TFAP4_ETV1 rsCGGAwgCAGsTGgk |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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