Transcription Factor

Accessions: FOSL2_HUMAN (HOCOMOCO 10), P15408 (JASPAR 2024)
Names: Fos-related antigen 2, FOSL2_HUMAN, FRA-2
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 326
Pfam Domains: 122-181 bZIP transcription factor
124-176 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDL 60
61 QWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLS 120
121 PEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKL 180
181 EFMLVAHGPVCKISPEERRSPPAPGLQPMRSGGGSVGAVVVKQEPLEEDSPSSSSAGLDK 240
241 AQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPGTSNLVFTYPSVLEQESPASPSESC 300
301 SKAHRRSSSSGDQSSDSLNSPTLLAL
Interface Residues: 130, 131, 134, 135, 137, 138, 141, 142, 145
3D-footprint Homologues: 7x5e_F, 2wt7_A, 2wt7_B, 4eot_A, 7x5e_E, 1nwq_C, 6mg1_B, 1skn_P, 5vpe_C, 5vpe_D, 2dgc_A
Binding Motifs: MA0478.1 krrTGAsTCAb
FOSL2_HUMAN.H10MO.A|M01140 rTGACTCAyyc
MA1130.1 kkrTGAGTCAym
MA1131.1 grTGACGTmAt
MA0478.2 rrTGAsTCAb
MA1130.2 rTGAGTCAy
MA1131.2 rTGACGTmAt
Binding Sites: MA0478.1.1
MA0478.1.10 / MA0478.1.7 / MA0478.1.8 / MA0478.1.9
MA0478.1.11
MA0478.1.12
MA0478.1.13
MA0478.1.14
MA0478.1.15
MA0478.1.16
MA0478.1.17
MA0478.1.18
MA0478.1.19
MA0478.1.2
MA0478.1.20
MA0478.1.3
MA0478.1.4
MA0478.1.5
MA0478.1.6
MA0478.2.1
MA0478.2.10 / MA0478.2.7 / MA0478.2.8 / MA0478.2.9
MA0478.2.11
MA0478.2.12
MA0478.2.13
MA0478.2.14
MA0478.2.15
MA0478.2.16
MA0478.2.17
MA0478.2.18
MA0478.2.19
MA0478.2.2
MA0478.2.20
MA0478.2.3
MA0478.2.4
MA0478.2.5
MA0478.2.6
Publications: Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed]

Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol : (2002). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.