Transcription Factor

						

			
Accessions: FOSB (SMILE-seq 1.0)

			
Names: FOSB, FOSB_HUMAN, G0/G1 switch regulatory protein 3, Protein fosB
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P53539
Notes: TF family: bZIP
Length: 337
Pfam Domains:   153-211 bZIP transcription factor
  155-207 Basic region leucine zipper
Sequence: 
(in bold interface residues)		   1 MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTA   60
  61 ITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGS  120
 121 GGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELT  180
 181 DRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRD  240
 241 LPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSY  300
 301 TSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLA
Interface Residues: 161, 162, 165, 166, 168, 169, 172, 173, 176
3D-footprint Homologues: 4eot_A, 7x5e_E, 5vpe_C, 7x5e_F, 2wt7_A, 6mg1_B, 1nwq_C, 1skn_P, 5t01_B, 5vpe_D
Binding Motifs: JUNB_FOSB_1 krTGAsTCAy
JUNB_FOSB_2 rTGACGTCAy
JUND_FOSB_1 taTgActmAtw
JUN_FOSB_1 krTGACTCAy
JUN_FOSB_2 gaTGACGTCAy
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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