Transcription Factor
Accessions: | O75364 (JASPAR 2024) |
Names: | Homeobox protein PITX3, Paired-like homeodomain transcription factor 3, Pituitary homeobox 3, PITX3_HUMAN |
Organisms: | Homo sapiens |
Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 302 |
Pfam Domains: | 63-119 Homeobox domain 257-275 OAR domain |
Sequence: (in bold interface residues) | 1 MEFGLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKK 60 61 KQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKR 120 121 ERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVG 180 181 PLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYA 240 241 SAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVHGPPPAANLSPCQYAVER 300 301 PV |
Interface Residues: | 16, 20, 62, 63, 64, 65, 66, 68, 104, 105, 107, 108, 111, 112, 115, 116, 119 |
3D-footprint Homologues: | 3l1p_A, 4j19_B, 1fjl_B, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 5zfz_A, 6fqp_B, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 6es3_K, 7q3o_C, 2hos_A, 5zjt_E, 3a01_E, 6m3d_C, 1b72_A, 5hod_A, 1ig7_A, 7psx_B, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1mnm_C, 4cyc_A, 2r5y_A, 1puf_B, 5flv_I, 1le8_B, 1k61_B, 1le8_A, 1e3o_C, 1o4x_A, 4qtr_D, 1du0_A |
Binding Motifs: | MA0714.1 vyTAATCCc MA0714.2 TAATCC |
Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.