Transcription Factor

Accessions: ELF1_full (HumanTF 1.0), ELF1_TF2 (HumanTF2 1.0)
Names: E74-like factor 1, ELF1, ELF1_HUMAN, ETS-related transcription factor Elf-1, E74-like factor 4, ELF4_HUMAN, ETS-related transcription factor Elf-4, Myeloid Elf-1-like factor
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P32519
Notes: Ensembl ID: ENSG00000120690; Full protein sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000120690; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013
Length: 596
Pfam Domains: 1-111 Transcription factor protein N terminal
184-267 Ets-domain
Sequence:
(in bold interface residues)
1 MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM 60
61 ITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRI 120
121 NGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKNKDGK 180
181 GNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETM 240
241 GRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYINDEDPSSSIESSDPSLSSSATSNRN 300
301 QTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFR 360
361 TVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQ 420
421 TVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLGPAQV 480
481 QQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPGTVITSVIKTQETKT 540
541 LTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSNGFTSQVAMKQNELLEPNSF*
Interface Residues: 238, 239, 241, 242, 243, 245, 246, 260, 427, 434, 446
3D-footprint Homologues: 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 8ee9_F, 1dux_F, 4uno_A, 3jtg_A, 4l18_B, 1awc_A, 4lg0_B, 1yo5_C, 4bqa_A, 1bc8_C, 4iri_A, 6fbc_A, 1tau_A
Binding Motifs: ELF1_full AACCCGGAAGTr
CEBPG_ELF1 TkrcghmAtwsMGGAAGt
FOXJ2_ELF1_1 rtaaACmGGAAGwr
FOXJ2_ELF1_2 rcAGAAAACCGAAwm
FOXJ3_ELF1 rcarAAAACCGAAwmv
FOXO1_ELF1_1 cagAAAACCGAAwm
FOXO1_ELF1_2 kTGTTGCCGGAAgkk
FOXO1_ELF1_2_3 rtmAACAGGAAgtd
GCM1_ELF1_1 rkGcGGGCGGAaGtr
GCM1_ELF1_2 kvCGGAArTGckGGt
GCM1_ELF1_2_3 crCCCrCACGGAAGtr
HOXB2_ELF1_1 smGGAAGTmrTta
HOXB2_ELF1_2 ggymATtArsrwksmGGAAGtr
HOXB2_ELF1_2_3 gymATyAgsgraksmGGAAGtr
HOXB2_ELF1_2_3_4 TaATkrwyvMGGAAGtr
HOXB2_ELF1_2_3_4_5 TrAtkrswrsmGGAAGtr
MEIS1_ELF1 vTGmCGGAAgyr
MYBL1_ELF1 amCCGGAACCGTTa
TEAD4_ELF1_1 rgAATGCGGAAGtr
TEAD4_ELF1_2 gGAATGCGGAAGtr
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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