Transcription Factor

Accessions: T100213_1.02 (CISBP 1.02), P53147 (JASPAR 2024)
Names: T100213_1.02;, TOS8, Homeobox protein TOS8, Target of SBF 8, TOS8_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Homeodomain
Length: 276
Pfam Domains: 197-251 Homeobox domain
212-251 Homeobox KN domain
Sequence:
(in bold interface residues)
1 MGTSIVNLNQKIELPPIQVLFESLNRENETKPHFEERRLYQPNPSFVPRTNIAVGSPVNP 60
61 VPVSSPVFFIGPSPQRSIQNHNAIMTQNIRQYPVIYNNNREVISTGERNYIITVGGPPVT 120
121 SSQPEYEHISTPNFYQEQRLAQPHPVNESMMIGGYTNPQPISISRGKMLSGNISTNSVRG 180
181 SNNGYSAKEKKHKAHGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQ 240
241 ISNWFINARRRKIFSGQNDANNFRRKFSSSTNLAKF
Interface Residues: 197, 198, 199, 242, 243, 246, 247, 248, 249, 250, 251, 264, 267
3D-footprint Homologues: 6fqp_B, 1puf_B, 1zq3_P, 7q3o_C, 7xrc_C, 1le8_A, 3cmy_A, 1le8_B, 5zfz_A, 2hdd_A, 1fjl_B, 3lnq_A, 1mnm_C, 5zjt_E, 1k61_B, 6fqq_E, 4xrm_B, 8g87_X, 6a8r_A, 2lkx_A, 4xrs_G, 1du0_A, 6es3_K, 2hos_A, 6m3d_C
Binding Motifs: M1136_1.02 wkACGTmAaat
MA0408.1 mTGTCAaa
MA0408.2 TGTCAa
Publications: Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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