Transcription Factor
| Accessions: | FOXI1_full (HumanTF 1.0), FOXI1_TF2 (HumanTF2 1.0) |
| Names: | A8K811_HUMAN, cDNA FLJ76677, highly similar to Homo sapiens forkhead box I1, FOXI1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | A8K811 |
| Notes: | Ensembl ID: ENSG00000168269; Full protein sequence; TF family: Forkhead; Clone source: Megaman, Ensembl ID: ENSG00000168269; Construct type: TF2(3xFLAG); TF family: Forkhead; Clone source: Jolma et al. 2013 |
| Length: | 379 |
| Pfam Domains: | 123-218 Fork head domain |
| Sequence: (in bold interface residues) | 1 MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPN 60 61 PYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMK 120 121 LVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDC 180 181 FKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPV 240 241 DSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLV 300 301 TPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHF 360 361 YNSVNTSGVLYPREGTEV* |
| Interface Residues: | 163, 166, 168, 169, 170, 172, 173, 174, 176, 177, 186, 193, 218 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 3qrf_G |
| Binding Motifs: | FOXI1_full_1 GTAAACA FOXI1_full_2 rTGTkTACGGTAAACAA CUX1_FOXI1 rTmawCAcgmkrATCRATt E2F3_FOXI1 tGACACCGCGCCCaC ELK1_FOXI1_1 AsCGGAArTrTmAACAk ELK1_FOXI1_2 rCCGGAAGsWmArCAk ELK1_FOXI1_2_3 rmCGGAAGTTkw ELK1_FOXI1_2_3_4 wGyTkmCGGAwGTk ELK1_FOXI1_2_3_4_5 ammGGAAayrTAAAyA ELK1_FOXI1_2_3_4_5_6 ammGGAAbrtAAACA ERF_FOXI1_1 rcCGGAwGTtkwy ERF_FOXI1_2 rtaaACmGGAArtr ERF_FOXI1_2_3 trTtkmCGGAart ETV2_FOXI1_1 sgtaaACAGGAwRyr ETV2_FOXI1_2 rCCGGAAGTmwACA ETV2_FOXI1_2_3 rcCGGAAryrtmmACAy ETV2_FOXI1_2_3_4 rcCGGATGTTkw ETV2_FOXI1_2_3_4_5 TGTtkmCGGAWGtg ETV5_FOXI1_1 GtMAACMGGAwGy ETV5_FOXI1_2 rsCGGAwGTkkw ETV5_FOXI1_2_3 tGtkkmCGGAwGt FLI1_FOXI1_1 GAAAACCGAAAM FLI1_FOXI1_2 rcCGGAWGTTkay FLI1_FOXI1_2_3 rtaAACAGGAwryd FLI1_FOXI1_2_3_4 TGTtkmCGGAwrtg GCM1_FOXI1_1 rTGTTGATrcGGGy GCM1_FOXI1_2 GTAAATAmGGGyr GCM1_FOXI1_2_3 ryGTMAATAvGGGyr GCM1_FOXI1_2_3_4 RTmAACATrcGGGy GCM1_FOXI1_2_3_4_5 TGTTGaTrcGGGt GCM2_FOXI1_1 rTAAATAmGGGya GCM2_FOXI1_2 TrTTkATrcGGGy TEAD4_FOXI1_1 GGwATGyGtmmACa TEAD4_FOXI1_2 rCATTCCryayhmygcmawmyrwmAACA TEAD4_FOXI1_2_3 GCATwCCryrmmmwsyymmyrTmAACA TEAD4_FOXI1_2_3_4 rCATTCCabmrmmavgrvmrtmmACA TEAD4_FOXI1_2_3_4_5 rCaTtCCacmcysrmAgYGmmmaCA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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