Transcription Factor
Accessions: | T049130_1.02 (CISBP 1.02), MTF1_MOUSE (HOCOMOCO 10), Q07243 (JASPAR 2024) |
Names: | Mtf1, T049130_1.02;, Metal regulatory transcription factor 1, MRE-binding transcription factor, MTF1_MOUSE, Transcription factor MTF-1 |
Organisms: | Mus musculus |
Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | Q07243 |
Notes: | experiment type:PBM, family:C2H2 ZF |
Length: | 675 |
Pfam Domains: | 139-163 Zinc finger, C2H2 type 139-163 C2H2-type zinc finger 155-182 Zinc-finger double domain 169-193 Zinc finger, C2H2 type 169-193 C2H2-type zinc finger 185-212 Zinc-finger double domain 199-223 Zinc finger, C2H2 type 199-223 C2H2-type zinc finger 216-241 Zinc-finger double domain 228-252 Zinc finger, C2H2 type 228-252 C2H2-type zinc finger 244-270 Zinc-finger double domain 258-282 C2H2-type zinc finger 258-282 Zinc finger, C2H2 type 274-301 Zinc-finger double domain 288-312 Zinc finger, C2H2 type 290-312 C2H2-type zinc finger |
Sequence: (in bold interface residues) | 1 MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLED 60 61 DEDDGQCGEPLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGA 120 121 TLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAF 180 181 LTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFT 240 241 TLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFS 300 301 TQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQD 360 361 LSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPL 420 421 VLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAAN 480 481 HQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGA 540 541 NSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYF 600 601 ATAVPVASGTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPE 660 661 PNPQPPDGPSLQLPP |
Interface Residues: | 152, 154, 155, 158, 181, 182, 183, 184, 185, 188, 192, 207, 209, 210, 212, 213, 214, 215, 217, 218, 220, 221, 222, 224, 240, 241, 242, 243, 244, 246, 247, 251, 270, 271, 272, 273, 274, 276, 277, 278, 281, 300, 301, 302, 303, 304, 305, 306, 307, 308, 311 |
3D-footprint Homologues: | 7w1m_H, 5und_A, 5v3j_F, 2i13_A, 6wmi_A, 8ssq_A, 8ssu_A, 6jnm_A, 2kmk_A, 5kkq_D, 1tf6_A, 5ei9_F, 6e94_A, 6a57_A, 5yel_A, 5k5i_A, 1mey_C, 2gli_A, 6ml4_A, 1g2f_F, 7eyi_G, 7ysf_A, 2jpa_A, 1ubd_C, 8cuc_F, 1tf3_A, 7y3l_A, 7n5w_A, 1f2i_J, 4x9j_A, 8gn3_A, 6blw_A, 6u9q_A, 7txc_E, 5kl3_A, 8h9h_G, 2lt7_A, 7y3m_I, 3uk3_C, 5k5l_F, 2wbs_A, 1llm_D, 4m9v_C, 5yj3_D |
Binding Motifs: | PB0044.1 kggyCGTGYGCAamdh PB0148.1 aaatawgAAawawv M0407_1.02 CGTGyGCAm MTF1_MOUSE.H10MO.C|M01214 mGkgcCGTGYGCAamrs |
Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.