Transcription Factor

Accessions: T049130_1.02 (CISBP 1.02), MTF1_MOUSE (HOCOMOCO 10), Q07243 (JASPAR 2024)
Names: Mtf1, T049130_1.02;, Metal regulatory transcription factor 1, MRE-binding transcription factor, MTF1_MOUSE, Transcription factor MTF-1
Organisms: Mus musculus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q07243
Notes: experiment type:PBM, family:C2H2 ZF
Length: 675
Pfam Domains: 139-163 Zinc finger, C2H2 type
139-163 C2H2-type zinc finger
155-182 Zinc-finger double domain
169-193 Zinc finger, C2H2 type
169-193 C2H2-type zinc finger
185-212 Zinc-finger double domain
199-223 Zinc finger, C2H2 type
199-223 C2H2-type zinc finger
216-241 Zinc-finger double domain
228-252 Zinc finger, C2H2 type
228-252 C2H2-type zinc finger
244-270 Zinc-finger double domain
258-282 C2H2-type zinc finger
258-282 Zinc finger, C2H2 type
274-301 Zinc-finger double domain
288-312 Zinc finger, C2H2 type
290-312 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLED 60
61 DEDDGQCGEPLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGA 120
121 TLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAF 180
181 LTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFT 240
241 TLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFS 300
301 TQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQD 360
361 LSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPL 420
421 VLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAAN 480
481 HQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGA 540
541 NSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYF 600
601 ATAVPVASGTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPE 660
661 PNPQPPDGPSLQLPP
Interface Residues: 152, 154, 155, 158, 181, 182, 183, 184, 185, 188, 192, 207, 209, 210, 212, 213, 214, 215, 217, 218, 220, 221, 222, 224, 240, 241, 242, 243, 244, 246, 247, 251, 270, 271, 272, 273, 274, 276, 277, 278, 281, 300, 301, 302, 303, 304, 305, 306, 307, 308, 311
3D-footprint Homologues: 7w1m_H, 5und_A, 5v3j_F, 2i13_A, 6wmi_A, 8ssq_A, 8ssu_A, 6jnm_A, 2kmk_A, 5kkq_D, 1tf6_A, 5ei9_F, 6e94_A, 6a57_A, 5yel_A, 5k5i_A, 1mey_C, 2gli_A, 6ml4_A, 1g2f_F, 7eyi_G, 7ysf_A, 2jpa_A, 1ubd_C, 8cuc_F, 1tf3_A, 7y3l_A, 7n5w_A, 1f2i_J, 4x9j_A, 8gn3_A, 6blw_A, 6u9q_A, 7txc_E, 5kl3_A, 8h9h_G, 2lt7_A, 7y3m_I, 3uk3_C, 5k5l_F, 2wbs_A, 1llm_D, 4m9v_C, 5yj3_D
Binding Motifs: PB0044.1 kggyCGTGYGCAamdh
PB0148.1 aaatawgAAawawv
M0407_1.02 CGTGyGCAm
MTF1_MOUSE.H10MO.C|M01214 mGkgcCGTGYGCAamrs
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.