Transcription Factor
| Accessions: | P31314 (JASPAR 2024) |
| Names: | Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia homeobox protein 1, T-cell leukemia/lymphoma protein 3, TLX1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P31314 |
| Length: | 330 |
| Pfam Domains: | 202-258 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG 60 61 GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS 120 121 GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN 180 181 RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM 240 241 TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN 300 301 SSLFALQNLQPWSDDSTKITSVTSVASACE |
| Interface Residues: | 191, 196, 201, 202, 203, 204, 205, 206, 243, 244, 246, 247, 250, 251, 254, 255, 258 |
| 3D-footprint Homologues: | 3a01_E, 4j19_B, 5zjt_E, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 1ig7_A, 3cmy_A, 5zfz_A, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 7psx_B, 5hod_A, 3lnq_A, 1b72_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 1puf_B, 1jgg_B, 5flv_I, 2hos_A, 1mnm_C, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 1k61_B, 6fqq_E, 1o4x_A, 4qtr_D, 6wig_A, 1du0_A, 6fqp_B |
| Binding Motifs: | MA0119.1 TGGCAssrwGCCAA |
| Binding Sites: | MA0119.1.1 MA0119.1.10 MA0119.1.11 MA0119.1.12 MA0119.1.13 MA0119.1.14 MA0119.1.15 MA0119.1.16 MA0119.1.2 MA0119.1.3 MA0119.1.4 MA0119.1.5 MA0119.1.6 MA0119.1.7 MA0119.1.8 MA0119.1.9 |
| Publications: | Zhang N, Shen W, Hawley R.G, Lu M. HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization. Oncogene 18:2273-9 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.